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Despite substantial progress in pharmacological treatment, including renin\u2013angiotensin\u2013aldosterone system (RAAS) inhibitors, beta\u2010blockers, sodium\u2013glucose cotransporter 2 (SGLT2) inhibitors, mineralocorticoid receptor antagonists (MRAs), diuretics, and antiarrhythmic drugs, many patients continue to experience residual symptoms and drug\u2010related adverse effects. Nutraceuticals have emerged as potential adjuncts to conventional therapy due to their ability to modulate key biological processes involved in HF and AF. Polyphenols from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Olea europaea<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Hibiscus sabdariffa<\/jats:italic>\n                    <\/jats:styled-content>\n                    ,\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Camellia sinensis<\/jats:italic>\n                    <\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Vitis vinifera<\/jats:italic>\n                    <\/jats:styled-content>\n                    (resveratrol) exhibit antioxidant, anti\u2010inflammatory, and vasoprotective effects. Omega\u20103 fatty acids and astaxanthin contribute to inflammation control and redox balance, while\n                    <jats:italic>Orthosiphon stamineus<\/jats:italic>\n                    and\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Taraxacum officinale<\/jats:italic>\n                    <\/jats:styled-content>\n                    show mild diuretic activity. Moreover, anthocyanins, ursolic acid, and\n                    <jats:italic>Rhodiola crenulata<\/jats:italic>\n                    may exert antifibrotic and antiarrhythmic properties. This review provides a mechanistic comparison between pharmacological agents and nutraceuticals with overlapping mechanisms of action, highlighting their potential role in integrative cardiovascular care. While nutraceuticals are not substitutes for established therapies, emerging evidence supports their complementary use in improving treatment response, reducing side effects, and enhancing patient outcomes. Future research should focus on large\u2010scale trials, improved bioavailability, standardized formulations, and the development of personalized therapeutic strategies. Challenges related to dosage consistency, clinical validation, and regulatory oversight are also addressed to guide innovation in integrative cardiology.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70433","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:27:01Z","timestamp":1788233221000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrative Approaches in Cardiovascular Disease: The Role of Nutraceuticals in Heart Failure, Atrial Fibrillation, and Related Conditions"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9932-6104","authenticated-orcid":false,"given":"Laura Beatrice","family":"Mattioli","sequence":"first","affiliation":[{"name":"Department of Pharmacy and Biotechnology (FaBiT), Food Chemistry and Nutraceutical Lab Alma Mater Studiorum\u2010University of Bologna  Bologna Italy"},{"name":"Health Sciences and 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