{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T01:14:31Z","timestamp":1788311671386,"version":"build-2803163510"},"reference-count":36,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"abstract":"ABSTRACT<\/jats:title>\n \n Oxyfil is a dietary supplement including plant extracts from\n \n Epilobium angustifolium<\/jats:styled-content>\n , Ptychopetalum olacoides (Muira puama),\n Ginkgo biloba<\/jats:styled-content>\n <\/jats:italic>\n , and\n \n Equisetum arvense<\/jats:italic>\n <\/jats:styled-content>\n and citrulline. The aim of the study was to investigate the protective effects on prostatic muscles of the Oxyfil formulation in an in\u00a0vitro experimental model consisting of isolated mouse prostate specimens exposed to\n \n Escherichia coli<\/jats:italic>\n <\/jats:styled-content>\n lipopolysaccharide (LPS) as a pro\u2010inflammatory stimulus. The study also assessed the tolerability and effectiveness of Oxyfil in alleviating lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH) when used in association with standard care. In the preclinical phase, Oxyfil was analysed via liquid chromatographic in order to identify and quantify phenolic compounds. Thereafter, the formulation was tested on isolated mouse prostate challenged with LPS in order to upregulate the gene expression of different pro\u2010inflammatory and oxidative stress biomarkers, namely COX\u20102, i\u2010NOS, TNF\u03b1, IL\u20106, VEGFA, HIF1\u03b1. The clinical trial was a retrospective, multicentre study. Fifty\u2010nine patients were analyzed: 27 received Oxyfil, 18 Oxyfil + \u03b1\u2010blocker, 7 Oxyfil + PDE5i, and 7 Oxyfil + 5\u2010ARI. Key inclusion criteria were age 50\u201375\u2009years, moderate to severe LUTS (IPSS), mild erectile dysfunction, and baseline\n Q<\/jats:italic>\n max<\/jats:sub>\n 4\u201315\u2009mL\/s; exclusions were endocrine\/hormonal erectile dysfunction, bladder\u2010neck sclerosis, and urethral stricture. Treatment selection was non\u2010randomized and left to the treating physician. The chromatographic analysis identified 25 phenolic compounds in the Oxyfil formulation. The total phenolic content can explain, albeit partially, the Oxyfil efficacy in blunting LPS\u2010induced upregulation of the gene expression of all tested biomarkers in isolated prostate. The protective effects demonstrated in the preclinical phase also support, albeit partially, the clinical efficacy in ameliorating uroflowmetry and symptom outcomes in the patients' cohort. In conclusion, the present study demonstrated anti\u2010inflammatory and antioxidant effects of the Oxyfil formulation in the prostate which corroborated the observed clinical outcomes.\n <\/jats:p>","DOI":"10.1002\/ptr.70438","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T00:34:36Z","timestamp":1788309276000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Protective Effects Induced by a Novel Food Supplement Based on\n \n Epilobium angustifolium<\/i>\n <\/scp>\n ,\n \n Ptychopetalum olacoides<\/i>\n <\/scp>\n ,\n \n Ginkgo biloba<\/i>\n <\/scp>\n , and\n \n Equisetum arvense<\/i>\n <\/scp>\n Extracts and Citrulline in the Lower Urinary Tract: Preclinical and Clinical Evidence"],"prefix":"10.1002","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3399-967X","authenticated-orcid":false,"given":"Annalisa","family":"Chiavaroli","sequence":"first","affiliation":[{"name":"Botanical Garden \u201cGiardino dei Semplici\u201d, Department of Pharmacy \u201cG. d'Annunzio\u201d University Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8776-1413","authenticated-orcid":false,"given":"Alessandra","family":"Acquaviva","sequence":"additional","affiliation":[{"name":"Botanical Garden \u201cGiardino dei Semplici\u201d, Department of Pharmacy \u201cG. d'Annunzio\u201d University Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5041-3848","authenticated-orcid":false,"given":"Simonetta Cristina Di","family":"Simone","sequence":"additional","affiliation":[{"name":"Botanical Garden \u201cGiardino dei Semplici\u201d, Department of Pharmacy \u201cG. d'Annunzio\u201d University Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Salvatore","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute University Vita and Salute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Messina","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute University Vita and Salute Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Morgante","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, IRCCS San Raffaele Scientific Institute University Vita and Salute Milan 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T\u00fcrkiye"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giustino","family":"Orlando","sequence":"additional","affiliation":[{"name":"Botanical Garden \u201cGiardino dei Semplici\u201d, Department of Pharmacy \u201cG. d'Annunzio\u201d University Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7346-7395","authenticated-orcid":false,"given":"Luigi","family":"Menghini","sequence":"additional","affiliation":[{"name":"Botanical Garden \u201cGiardino dei Semplici\u201d, Department of Pharmacy \u201cG. d'Annunzio\u201d University Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9431-9407","authenticated-orcid":false,"given":"Claudio","family":"Ferrante","sequence":"additional","affiliation":[{"name":"Botanical Garden \u201cGiardino dei Semplici\u201d, Department of Pharmacy \u201cG. d'Annunzio\u201d University Chieti\u2010Pescara Chieti Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Schips","sequence":"additional","affiliation":[{"name":"UniCamillus International University of Health Sciences Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0712-2719","authenticated-orcid":false,"given":"Luca","family":"Cindolo","sequence":"additional","affiliation":[{"name":"Centro Urologico Europeo Modena Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1702-4127","authenticated-orcid":false,"given":"Michele","family":"Marchioni","sequence":"additional","affiliation":[{"name":"UniCamillus International University of Health Sciences Rome 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