{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T02:02:18Z","timestamp":1789956138693,"version":"4.0.1"},"reference-count":172,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:00:00Z","timestamp":1789862400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Plant\u2010derived natural products have emerged as important sources of anticancer agents because of their diverse chemical structures and broad biological activities. However, their clinical application is often limited by poor aqueous solubility, low membrane permeability, insufficient tumor selectivity, and systemic toxicity. Recent advances in nanodelivery systems have provided effective strategies to overcome these pharmacokinetic and pharmacodynamic barriers by improving drug stability, enhancing tumor\u2010targeted accumulation, and promoting intracellular delivery. In this review, we systematically summarise recent progress in the nanotechnology\u2010based delivery of plant\u2010derived natural products for cancer therapy, with a focus on three major strategies: chemical conjugation, self\u2010assembly of natural products, and codelivery of natural products with chemotherapeutic agents. We further discuss the major advantages of these systems, including improved bioavailability, enhanced targeting capacity, reduced off\u2010target toxicity, and the potential to overcome multidrug resistance. Finally, current challenges in formulation design, safety evaluation, large\u2010scale manufacturing, and clinical translation are highlighted. This review provides a comprehensive framework for the rational development of plant\u2010derived natural product nanomedicines in precision oncology.<\/jats:p>","DOI":"10.1002\/ptr.70441","type":"journal-article","created":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T01:54:33Z","timestamp":1789955673000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Plant\u2010Derived Natural Product Nanodelivery System in Cancer Therapy"],"prefix":"10.1002","author":[{"given":"Changqi","family":"Shi","sequence":"first","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"LuLu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Yan","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1580-5728","authenticated-orcid":false,"given":"Qi","family":"Geng","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0553-0919","authenticated-orcid":false,"given":"Xiaojuan","family":"He","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Zhao","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tan","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomeng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6474-9198","authenticated-orcid":false,"given":"Cheng","family":"Lu","sequence":"additional","affiliation":[{"name":"Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,20]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/17425247.2020.1822321","article-title":"Surface\u2010Modified Polymeric Nanoparticles for Drug Delivery to Cancer Cells","volume":"18","author":"Ahmed A.","year":"2021","journal-title":"Expert Opinion on Drug Delivery"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1515\/dmpt\u20102018\u20100032"},{"key":"e_1_2_11_4_1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.addr.2012.09.037","article-title":"Liposomal Drug Delivery Systems: From Concept to Clinical Applications","volume":"65","author":"Allen T. 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