{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:09:08Z","timestamp":1790262548525,"version":"4.1.0"},"reference-count":61,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T00:00:00Z","timestamp":1790208000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82505061"],"award-info":[{"award-number":["82505061"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Alzheimer's disease (AD) remains a progressive neurodegenerative disorder with limited therapeutic options. Ginsenoside Rh1 has been reported to possess neuroprotective properties, yet its specific role and underlying mechanisms in AD are not fully understood. This study aimed to investigate the protective effects of Rh1 against AD\u2010related deficits and elucidate its molecular mechanisms. Using a D\u2010galactose and AlCl\n                    <jats:sub>3<\/jats:sub>\n                    \u2010induced AD\u2010like mouse model and an okadaic acid (OA)\u2010injured HT22 hippocampal neuronal cell model, we demonstrated that Rh1 administration significantly ameliorated spatial learning and memory impairments, reduced hippocampal neuronal damage, and suppressed abnormal Tau hyperphosphorylation. Serum metabolomics analysis revealed that Rh1 markedly modulated amino acid metabolism pathways in AD\u2010like mice, notably increasing aspartate (Asp) levels and decreasing glutamate (Glu) levels. Mechanistically, Rh1 activated the Nrf2 antioxidant pathway, thereby alleviating cellular oxidative stress. Concurrently, Rh1 ameliorated mitochondrial dysfunction by enhancing mitochondrial biogenesis, improving the mitochondrial fusion\u2010fission balance, and modulating mitophagy. Importantly, the SIRT1 inhibitor EX\u2010527 and SIRT1 knockdown both significantly reversed these protective effects. Cellular thermal shift assay and molecular docking suggested a potential interaction between Rh1 and SIRT1. In conclusion, our findings indicate that ginsenoside Rh1 exerts neuroprotective effects against AD in\u00a0vivo and in\u00a0vitro, at least partly through SIRT1\u2010related signaling, which subsequently attenuates oxidative stress and ameliorates mitochondrial dysfunction. These results suggest that Rh1 may represent a promising candidate for further investigation for AD intervention.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70459","type":"journal-article","created":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T14:46:31Z","timestamp":1790261191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ginsenoside Rh1 Attenuates Alzheimer's Disease\u2010Like Deficits by Modulating Oxidative Stress and Mitochondrial Dysfunction via\n                    <scp>SIRT1<\/scp>\n                    \u2010Related Signaling"],"prefix":"10.1002","author":[{"given":"Shi\u2010Lu","family":"Li","sequence":"first","affiliation":[{"name":"College of Chinese Medicinal Materials, Jilin Provincial International Joint Research Center for the Development and Utilization of Authentic Medicinal Materials Jilin Agricultural University  Changchun 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