{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:57:00Z","timestamp":1790852220679,"version":"4.1.0"},"reference-count":219,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Chronic inflammation is a pathological mechanism of central importance that underpins a wide range of diseases, including neurodegenerative, cardiovascular, respiratory, gastrointestinal, and dermatological disorders.\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Ginkgo biloba<\/jats:italic>\n                    <\/jats:styled-content>\n                    extract (GBE), a standardized formulation derived from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Ginkgo biloba<\/jats:italic>\n                    <\/jats:styled-content>\n                    leaves, has attracted growing attention due to its anti\u2010inflammatory, antioxidant, and neuroprotective properties. This review comprehensively summarizes the current preclinical and clinical evidence regarding the therapeutic potential of GBE and its active constituents in inflammation\u2010related diseases. GBE has been shown to attenuate pro\u2010inflammatory cytokine production, suppress nuclear factor kappa B (NF\u2010\u03baB) activation, restore redox homeostasis, and modulate disease\u2010relevant pathways in models of Alzheimer's disease, Parkinson's disease, multiple sclerosis, atherosclerosis, asthma, chronic obstructive pulmonary disease, inflammatory bowel disease, inflammatory skin conditions and rheumatoid arthritis. While these findings highlight the promising multi\u2010targeted anti\u2010inflammatory actions of GBE, limitations remain regarding the identification of specific active compounds, standardization of formulations, and the availability of robust clinical evidence. Further research is warranted to clarify the mechanisms of action and optimize delivery of GBE, and to validate the efficacy and safety of GBE in large\u2010scale clinical trials.\n                  <\/jats:p>","DOI":"10.1002\/ptr.70467","type":"journal-article","created":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T10:06:45Z","timestamp":1790849205000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Potential of\n                    <scp>\n                      <i>Ginkgo biloba<\/i>\n                    <\/scp>\n                    Extract to Intervene in Chronic Inflammation\u2010Related Diseases"],"prefix":"10.1002","author":[{"given":"Yipeng","family":"Lin","sequence":"first","affiliation":[{"name":"Molecular Drug Development Group, Sydney Pharmacy School The University of Sydney  Sydney New South Wales 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0776-1630","authenticated-orcid":false,"given":"Ling","family":"Zhu","sequence":"additional","affiliation":[{"name":"Save Sight Institute, Faculty of Medicine and Health The University of Sydney  Sydney New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenchang","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Prince of Wales Hospital  Randwick New South Wales Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4233-7619","authenticated-orcid":false,"given":"Michael","family":"Murray","sequence":"additional","affiliation":[{"name":"Molecular Drug Development Group, Sydney Pharmacy School The University of Sydney  Sydney New South Wales 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