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However, the efficacy of ABA against allergic airway inflammation and the underlying mechanism remain unknown. Herein, an OVA\u2010induced murine allergic airway inflammation model was established and treated with ABA in the presence or absence of PPAR\u2010\u03b3 antagonist GW9662. The results showed that ABA effectively stunted the development of airway inflammation, and concordantly downregulated OVA\u2010induced activation of NLRP3 inflammasome, suppressed oxidative stress and decreased the expression of mitochondrial fusion\/fission markers including Optic Atrophy 1 (OPA1), Mitofusion 2 (Mfn2), dynamin\u2010related protein 1 (DRP1) and Fission 1 (Fis1). Moreover, ABA treatment further increased OVA\u2010induced expression of PPAR\u2010\u03b3, while GW9662 abrogated the inhibitory effect of ABA on allergic airway inflammation as well as on the activation of NLRP3 inflammasome and oxidative stress. Consistently, ABA inhibited the activation of NLRP3 inflammasome, suppressed oxidative stress and mitochondrial fusion\/fission in LPS\u2010stimulated Raw264.7 cells via PPAR\u2010\u03b3. Collectively, ABA ameliorates OVA\u2010induced allergic airway inflammation in a PPAR\u2010\u03b3 dependent manner, and such effect of ABA may be associated with its inhibitory effect on NLRP3 inflammasome and oxidative stress. Our results suggest the potential of ABA or ABA\u2010rich food in protecting against asthma.<\/jats:p>","DOI":"10.1002\/ptr.7051","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T02:30:34Z","timestamp":1613269834000},"page":"3298-3309","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Abscisic acid suppresses the activation of <scp>NLRP3<\/scp> inflammasome and oxidative stress in murine allergic\u00a0airway\u00a0inflammation"],"prefix":"10.1002","volume":"35","author":[{"given":"Cui\u2010Cui","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Geriatric Respiratory and Critical Care, Anhui Geriatric Institute The First Affiliated Hospital of Anhui Medical University  Hefei China"},{"name":"Key Laboratory of Respiratory Disease Research and Medical Transformation of Anhui Province  Hefei 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