{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:07:07Z","timestamp":1791893227392,"version":"4.3.4"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T00:00:00Z","timestamp":1615852800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Gastrointestinal discomfort (GD), which often includes gastroesophageal reflux disease (GERD), is a common disorder in healthy adults affecting 40% of the worldwide population. The symptoms related to GD can have a negative impact on the quality of life (QoL). Current treatments for GERD are associated with side effects. We conducted a randomized double\u2010blind placebo\u2010controlled trial to assess the effect of a standardized extract of<jats:italic>Opuntia ficus\u2010indica<\/jats:italic>L. cladodes and<jats:italic>Olea europaea<\/jats:italic>L. leaves on the symptoms and QoL of healthy adults with GD. One hundred healthy participants with GD were enrolled in the study and divided into two groups: 60 participants taking<jats:italic>verum<\/jats:italic>(400\u2009mg\/day) and 40 taking the placebo for 8\u2009weeks. The Gastrointestinal Quality of Life index (GIQLI) and GERD Symptom Assessment Scale (GSAS) questionnaires were administered at the beginning of the study and after 4 and 8\u2009weeks. The group treated with<jats:italic>verum<\/jats:italic>experienced a statistically significant improvement of GIQLI and GSAS scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). Moreover, the effect size measured revealed a clinical significance. A day\u2010dependent improvement of symptoms was also observed. The standardized extract represents a fast, effective, and well\u2010tolerated treatment for improving symptoms related to GD and GERD.<\/jats:p>","DOI":"10.1002\/ptr.7074","type":"journal-article","created":{"date-parts":[[2021,3,16]],"date-time":"2021-03-16T11:58:03Z","timestamp":1615895883000},"page":"3756-3768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["A standardized extract of<scp><i>Opuntia ficus\u2010indica<\/i><\/scp>(L.) Mill and<scp><i>Olea europaea<\/i><\/scp>L. improves gastrointestinal discomfort: A<scp>double\u2010blinded randomized\u2010controlled<\/scp>study"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6733-0587","authenticated-orcid":false,"given":"Giuseppe Antonio","family":"Malfa","sequence":"first","affiliation":[{"name":"Department of Drug and Health Sciences University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Di Giacomo","sequence":"additional","affiliation":[{"name":"Department of Drug and Health Sciences University of Catania Catania Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigi","family":"Cardia","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphological and Functional Imaging University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela Elisa","family":"Sorbara","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphological and Functional Imaging University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Mannucci","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphological and Functional Imaging University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8116-4821","authenticated-orcid":false,"given":"Gioacchino","family":"Calapai","sequence":"additional","affiliation":[{"name":"Department of Biomedical and Dental Sciences and Morphological and Functional Imaging University of Messina Messina Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.11.125"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000505508"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2581461"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2017.1365073"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.3.444"},{"key":"e_1_2_9_7_1","volume-title":"Statistical power analysis for the behavioural sciences","author":"Cohen J.","year":"1988"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1015815102175"},{"key":"e_1_2_9_9_1","first-page":"135","article-title":"Attenuation of cold restraint stress\u2010induced gastric lesions by an olive leaf extract","volume":"28","author":"Dekanski D.","year":"2009","journal-title":"General Physiology and Biophysics"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2016.09.073"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1753-4887.2009.00248.x"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2010.04406.x"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.32859\/era.20.25.1-14"},{"issue":"4","key":"e_1_2_9_14_1","first-page":"264","article-title":"The gastrointestinal quality of life index. 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