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To date there are no effective vaccines or specific treatments against this highly contagious virus; therefore, there is an urgent need to advocate novel prophylactic or therapeutic interventions for COVID\u201019. This brief opinion critically discusses the potential of Silymarin, a flavonolignan with diverse pharmacological activity having antiinflammatory, antioxidant, antiplatelet, and antiviral properties, with versatile immune\u2010cytokine regulatory functions, that able to bind with transmembrane protease serine 2 (TMPRSS2) and induce endogenous antiviral cytokine interferon\u2010stimulated gene 15, for the management of COVID\u201019. Silymarin inhibits the expression of host cell surface receptor TMPRSS2 with a docking binding energy corresponding to \u22121,350.61\u2009kcal\/mol and a full fitness score of \u22128.11. The binding affinity of silymarin with an impressive virtual score exhibits significant potential to interfere with SARS\u2010CoV\u20102 replication. We propose in\u2010depth pre\u2010clinical and clinical review studies of silymarin for the development of anti\u2010COVID\u201019 lead, based on its clinical manifestations of COVID\u201019 and multifaceted bioactivities.<\/jats:p>","DOI":"10.1002\/ptr.7084","type":"journal-article","created":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T04:45:56Z","timestamp":1617597956000},"page":"4246-4257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Phyto\u2010pharmacological perspective of Silymarin: A potential prophylactic or therapeutic agent for <scp>COVID<\/scp>\u201019, based on its promising immunomodulatory, anti\u2010coagulant and anti\u2010viral property"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7544-391X","authenticated-orcid":false,"given":"Partha","family":"Palit","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, Drug Discovery Research Laboratory Assam University  Silchar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aparna","family":"Mukhopadhyay","sequence":"additional","affiliation":[{"name":"Department of Life Sciences Presidency University  Kolkata India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7999-329X","authenticated-orcid":false,"given":"Debprasad","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Division of Microbiology &amp; Virology ICMR\u2010National Institute of Traditional Medicine  Belagavi Karnataka India"},{"name":"Division of Virology ICMR\u2010National Institute of Cholera and Enteric Diseases, Beliaghata  Kolkata West Bengal India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,4]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6171"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.12050"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgm042"},{"issue":"12","key":"e_1_2_8_5_1","first-page":"1483","article-title":"Ameliorative effects of silymarin on HCl\u2010induced acute lung injury in rats; role of the Nrf\u20102\/HO\u20101 pathway","volume":"22","author":"Ahmed R. 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