{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:05:18Z","timestamp":1790906718779,"version":"4.1.0"},"reference-count":17,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,3,28]],"date-time":"2021-03-28T00:00:00Z","timestamp":1616889600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>In December 2019, an outbreak of coronavirus disease 2019 (COVID\u201019) occurred in Wuhan, China, with a rapid increase in cases worldwide. Until now, among several drugs tested, none demonstrated sufficient efficacy for its etiological treatment. Greater celandine (<jats:italic>Chelidonium majus<\/jats:italic> L.) is a well\u2010known medicinal plant, traditionally indicated for digestive disorders and topically to remove warts. This study, performed at private offices in S\u00e3o Paulo and Aracaju (Brazil), describes 20 consecutive COVID\u201019 outpatients treated with greater celandine and their clinical evolution. The patients, aged 14\u201371\u2009years (median of 41\u2009years), were treated with <jats:italic>Chelidonium majus<\/jats:italic> 10% mother tincture, 20\u201330 drops three times a day for 3\u201312\u2009days (median of 5\u2009days). Clinical features were assessed during the treatment and at least until 1\u2009week after its end. These cases were considered mild, as most COVID\u201019 cases. The symptoms were mainly fever, fatigue, cough, sore throat, coryza, anosmia, ageusia, and headache. Ten patients had comorbidities, such as hypertension, diabetes, and overweight. Complete or almost complete clinical improvement occurred within 1\u20139\u2009days of treatment (median of 3\u2009days). There were no adverse events. This casuistry, although small, may inspire other researchers to continue investigating <jats:italic>Chelidonium majus<\/jats:italic> as a healing treatment for COVID\u201019.<\/jats:p>","DOI":"10.1002\/ptr.7085","type":"journal-article","created":{"date-parts":[[2021,3,29]],"date-time":"2021-03-29T01:07:13Z","timestamp":1616980033000},"page":"3792-3798","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Greater celandine (<scp><i>Chelidonium majus<\/i><\/scp> L.) for <scp>COVID<\/scp>\u201019: A twenty\u2010case series"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1114-6841","authenticated-orcid":false,"given":"Nilo E.","family":"Gardin","sequence":"first","affiliation":[{"name":"Associa\u00e7\u00e3o Brasileira de Medicina Antropos\u00f3fica (Brazilian Association of Anthroposophic Medicine)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne Jacqueline","family":"Braga","sequence":"additional","affiliation":[{"name":"Associa\u00e7\u00e3o Brasileira de Medicina Antropos\u00f3fica (Brazilian Association of Anthroposophic Medicine)  Belo Horizonte Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,28]]},"reference":[{"key":"e_1_2_9_2_1","volume-title":"The complete German commission E monographs: Therapeutic guide to herbal medicines","author":"Blumenthal M.","year":"1998"},{"key":"e_1_2_9_3_1","volume-title":"Principles and practice of phytotherapy. 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