{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T14:58:35Z","timestamp":1790089115922,"version":"4.0.1"},"reference-count":57,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T00:00:00Z","timestamp":1617753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>Geraniol, an acyclic monoterpene present in several plant species' essential oils, is utilized as a food additive. It possesses potent antiproliferative and antitumor effects ascribed to its antiinflammatory, and antioxidant properties. The study aimed to understand geraniol's mechanism in human lung and skin cancer cells by employing molecular and cell target\u2010based assays. SRB, NRU, MTT assays, qRT\u2010PCR, molecular docking, and EAC model were used. Geraniol inhibits the proliferation of PC\u20103, A431, and A549 cells (~50%) and suppresses the activity of ornithine decarboxylase (15.42\u2009\u00b1\u20090.61\u2009\u03bcM) and hyaluronidase (57.61\u2009\u00b1\u20098.53\u2009\u03bcM) in A549 cells; LOX\u20105 (25.44\u2009\u00b1\u20093.50\u2009\u03bcM) and hyaluronidase (90.71\u2009\u00b1\u20092.38\u2009\u03bcM) in A431 cells. The qRT\u2010expression analysis of the targeted gene depicts non\u2010significant change at the transcriptional level of LOX\u20105 in A431 cells. A robust binding interaction of geraniol with molecular targets was observed in the molecular docking studies. In Ehrlich Ascites Carcinoma model, geraniol inhibit tumor growth by 50.08% at 75\u2009mg\/kg bw and was found to be safe up to 1,000\u2009mg\/kg bw in a toxicity study. Geraniol has two prenyl units allied head\u2010to\u2010tail and functionalized with one hydroxyl group at its tail end could be responsible for the antiproliferative activity. These observations provide evidence for geraniol to be used as a new prototype to develop a novel anticancer agent.<\/jats:p>","DOI":"10.1002\/ptr.7094","type":"journal-article","created":{"date-parts":[[2021,4,7]],"date-time":"2021-04-07T10:26:03Z","timestamp":1617791163000},"page":"3861-3874","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Geraniol exerts its antiproliferative action by modulating molecular targets in lung and skin carcinoma cells"],"prefix":"10.1002","volume":"35","author":[{"given":"Kaneez","family":"Fatima","sequence":"first","affiliation":[{"name":"Bioprospection and Product Development Division CSIR\u2010Central Institute of Medicinal and Aromatic Plants Lucknow India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahoor Ahmad","family":"Wani","sequence":"additional","affiliation":[{"name":"Bioprospection and Product Development Division CSIR\u2010Central Institute of Medicinal and Aromatic Plants Lucknow India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1014-1486","authenticated-orcid":false,"given":"Abha","family":"Meena","sequence":"additional","affiliation":[{"name":"Bioprospection and Product Development Division CSIR\u2010Central Institute of Medicinal and Aromatic Plants Lucknow India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6568-8107","authenticated-orcid":false,"given":"Suaib","family":"Luqman","sequence":"additional","affiliation":[{"name":"Bioprospection and Product Development Division CSIR\u2010Central Institute of Medicinal and Aromatic Plants Lucknow India"},{"name":"Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.57.7.2101-2103.1991"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-4610"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-10-499"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11745-997-0019-y"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2008.112797"},{"key":"e_1_2_10_7_1","first-page":"197","article-title":"Geraniol, a component of plant essential oils, inhibits growth and polyamine biosynthesis in human colon cancer cells","volume":"298","author":"Carnesecchi S.","year":"2001","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jat.2739"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijo.2016.3427"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2012-0076"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109029"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)52721-1"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568009616666161229145115"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.33552\/ICBC.2020.01.000510","article-title":"Antitumor activity of novel azole compound against Ehrlich ascites carcinoma in Swiss albino mice","volume":"1","author":"ELAblack F. Z.","year":"2020","journal-title":"Insight in Chemistry and Biochemistry"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.01.131"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S107490"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601910392989"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/01635581.2014.916320"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2018.03.014"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-59745-145-1_19"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867043455846"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(67)90179-0"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/zeb.2013.0876"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2018.03.063"},{"key":"e_1_2_10_25_1","first-page":"1683","article-title":"Geraniol induces cooperative interaction of apoptosis and autophagy to elicit cell death in PC\u20103 prostate cancer cells","volume":"40","author":"Kim S. H.","year":"2012","journal-title":"The International Journal of Oncology"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(83)90025-4"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.864"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0750-6907"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2013.06.007"},{"key":"e_1_2_10_30_1","first-page":"1","article-title":"A modified spectrophotometric and methodical approach to find novel inhibitors of ornithine decarboxylase enzyme: A path through the maze","volume":"10","author":"Luqman S.","year":"2013","journal-title":"Protocol Exchange"},{"key":"e_1_2_10_31_1","first-page":"53","article-title":"Effect of amiloride on the osmotic fragility and sodium\/potassium adenosine triphosphatase activity of erythrocytes","volume":"16","author":"Luqman S.","year":"2004","journal-title":"Asia Pacific Journal of Pharmacology"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1139\/cjpp-2016-0528"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2013.02.048"},{"key":"e_1_2_10_34_1","first-page":"255","article-title":"Chemopreventive potential of geraniol in 7,12\u2010dimethylbenz(a) anthracene (DMBA) induced skin carcinogenesis in Swiss albino mice","volume":"33","author":"Manoharan S.","year":"2012","journal-title":"The Journal of Environmental Biology"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.08.008"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(05)80842-3"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0074-02762009000600010"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-23669-9"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-987X(19981115)19:14<1639::AID-JCC10>3.0.CO;2-B"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.12.027"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2019.105457"},{"key":"e_1_2_10_43_1","first-page":"346","article-title":"Geraniol and geranyl acetate induce potent anticancer effects in colon cancer Colo\u2010205 cells by inducing apoptosis, DNA damage and cell cycle arrest","volume":"23","author":"Qi F.","year":"2018","journal-title":"Journal of BUON"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.4238\/gmr16039777"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700609"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(00)01168-6"},{"key":"e_1_2_10_47_1","first-page":"37","article-title":"Preventive effect of geraniol on diethylnitrosamine\u2010induced hepatocarcinogenesis in rats","volume":"59","author":"Sawada S.","year":"2016","journal-title":"YonagoActaMedica"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/705451"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12291-016-0601-x"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/82.13.1107"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1974.tb03762.x"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0022836"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/1750-3841.14665"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.111986"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2015.11.016"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.1.5"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666151102103305"},{"key":"e_1_2_10_58_1","first-page":"759","article-title":"Amentoflavone inhibits osteoclastogenesis and wear debris\u2010induced osteolysis via suppressing NF\u2010\u03baB and MAPKs signaling pathways","volume":"84","author":"Zhang Z.","year":"2018","journal-title":"PlantaMedica"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7094","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.7094","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7094","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T19:44:10Z","timestamp":1698867850000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.7094"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,7]]},"references-count":57,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["10.1002\/ptr.7094"],"URL":"https:\/\/doi.org\/10.1002\/ptr.7094","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,7]]},"assertion":[{"value":"2020-10-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}