{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T15:27:36Z","timestamp":1778858856903,"version":"3.51.4"},"reference-count":34,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,25]],"date-time":"2021-04-25T00:00:00Z","timestamp":1619308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>The study aimed to ascertain the effects of delta\u2010tocotrienol (\u03b4T3) supplementation on glycemic control, oxidative stress, inflammation and related micro\u2010ribonucleic acid (miRNA) expression in patients with type 2 diabetes mellitus (T2DM). Total 110 patients of T2DM on oral hypoglycemic agents, were randomly divided into tocotrienol and placebo groups and given 250\u2009mg \u03b4T3 or cellulose soft gel capsule once daily respectively for 24\u2009weeks. Glycemic control, oxidative stress, inflammatory biomarkers, and miRNAs expression were measured in serum at baseline and end of the intervention by using standard laboratory methods. Compared to the placebo, \u03b4T3 supplementation resulted in a significant (<jats:italic>p<\/jats:italic>\u00a0\u2264\u2009.05) reduction [mean difference (95% confidence interval)] in plasma glucose [\u22120.48 (\u22120.65, \u22120.30)], insulin [\u22121.19 (\u22121.51, \u22120.87)], homeostatic model assessment of insulin resistance [\u22120.67 (<jats:bold>\u2212<\/jats:bold>0.86, \u22120.49)], glycosylated hemoglobin [\u22120.53 (\u22120.79, \u22120.28)], malondialdehyde [\u22120.34 (\u22120.45, \u22120.22)], high sensitive\u2010C\u2010reactive protein[\u22120.35 (<jats:bold>\u2212<\/jats:bold>0.54, \u22120.16)], tumor necrosis factor\u2010alpha [\u22121.22 (<jats:bold>\u2212<\/jats:bold>1.62, \u22120.83)], and interleukin\u20106[\u22122.30 (<jats:bold>\u2212<\/jats:bold>2.91, \u22121.68)]. More than twofold downregulation in miRNA\u2010375, miRNA\u201034a, miRNA\u201021, and upregulation in miRNA\u2010126, miRNA\u2010132 expression was observed in the \u03b4T3 group compared to the placebo. The study demonstrated that \u03b4T3 supplementation in addition to oral hypoglycemic agents, improved glycemic control, inflammation, oxidative stress, and miRNA expression in T2DM without any adverse effect. Thus, \u03b4T3 might be considered as an effective dietary supplement to prevent long\u2010term diabetic complications.<\/jats:p>","DOI":"10.1002\/ptr.7113","type":"journal-article","created":{"date-parts":[[2021,4,26]],"date-time":"2021-04-26T04:28:17Z","timestamp":1619411297000},"page":"3968-3976","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Effects of <scp>delta\u2010tocotrienol<\/scp> supplementation on <i>Glycemic Control<\/i>, oxidative stress, inflammatory biomarkers and <scp>miRNA<\/scp> expression in type 2 diabetes mellitus: A randomized control trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Wajiha","family":"Mahjabeen","sequence":"first","affiliation":[{"name":"Department of Chemical Pathology, Armed Forces Institute of Pathology National University of Medical Sciences  Rawalpindi 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