{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T18:51:00Z","timestamp":1792263060623,"version":"4.4.0"},"reference-count":31,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2021,4,15]],"date-time":"2021-04-15T00:00:00Z","timestamp":1618444800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004048","name":"Kashan University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004048","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:p>The outbreak of Coronavirus disease 2019 (COVID\u201019) has caused a global health crisis. Nevertheless, no antiviral treatment has yet been proven effective for treating COVID\u201019 and symptomatic supportive cares have been the most common treatment. Therefore, the present study was designed to evaluate the effects of propolis and <jats:italic>Hyoscyamus niger<\/jats:italic> L. extract in patients with COVID\u201019. This randomized clinical trial was conducted on 50 cases referred to Akhavan and Sepehri Clinics, Kashan university of medical sciences, Iran. Subjects were divided into two groups (intervention and placebo). This syrup (containing 1.6\u2009mg of methanolic extract along with 450\u2009mg of propolis per 10\u2009mL) was administered three times a day to each patient for 6\u2009days. The clinical symptoms of COVID\u201019 such as: dry cough, shortness of breath, sore throat, chest pain, fever, dizziness, headache, abdominal pain, and diarrhea were reduced with propolis plus <jats:italic>Hyoscyamus niger<\/jats:italic> L. extract than the placebo group. However, the administration of syrup was not effective in the control of nausea and vomiting. In conclusion, syrup containing propolis and <jats:italic>Hyoscyamus niger<\/jats:italic> L. extract had beneficial effects in ameliorating the signs and symptoms of COVID\u201019 disease, in comparison with placebo groups.<\/jats:p>","DOI":"10.1002\/ptr.7116","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T20:27:08Z","timestamp":1618604828000},"page":"4000-4006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["The effect of propolis plus <scp><i>Hyoscyamus niger<\/i><\/scp> L. methanolic extract on clinical symptoms in patients with acute respiratory syndrome suspected to <scp>COVID<\/scp>\u201019: A clinical trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Morteza","family":"Kosari","sequence":"first","affiliation":[{"name":"Department of Biology Science and Research Branch, Islamic Azad University  Tehran Iran"},{"name":"Gametogenesis Research Center Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehdi","family":"Noureddini","sequence":"additional","affiliation":[{"name":"Physiology Research Center Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Peyman","family":"Khamechi","sequence":"additional","affiliation":[{"name":"Department of Persian Medicine, School of Persian Medicine Tehran University of Medical Sciences  Tehran Iran"},{"name":"Evidence Based Integrative Medicine Research Center Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad","family":"Najafi","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, School of Medicine Kashan University of Medical sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9193-6039","authenticated-orcid":false,"given":"Amir","family":"Ghaderi","sequence":"additional","affiliation":[{"name":"Clinical Research Development Unit\u2010Matini\/Kargarnejad Hospital Kashan University of Medical Sciences  Kashan Iran"},{"name":"Department of Addiction Studies, School of Medical Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mojtaba","family":"Sehat","sequence":"additional","affiliation":[{"name":"Trauma Research Center Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4450-8861","authenticated-orcid":false,"given":"Hamid Reza","family":"Banafshe","sequence":"additional","affiliation":[{"name":"Physiology Research Center Kashan University of Medical Sciences  Kashan Iran"},{"name":"Department of Addiction Studies, School of Medical Kashan University of Medical Sciences  Kashan Iran"},{"name":"Department of Pharmacology, School of Medicine Kashan University of Medical Sciences  Kashan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,4,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.138996"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200642"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.138861"},{"key":"e_1_2_10_5_1","first-page":"18","article-title":"Therapeutic importance of Hyoscyamus species grown in Iraq (Hyoscyamus albus, Hyoscyamus niger L. and Hyoscyamus reticulates)\u2014A review","volume":"8","author":"Al\u2010Snafi A. 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