{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T22:41:10Z","timestamp":1777502470432,"version":"3.51.4"},"reference-count":111,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,4,29]],"date-time":"2021-04-29T00:00:00Z","timestamp":1619654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["301354\/2019\u20107"],"award-info":[{"award-number":["301354\/2019\u20107"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["306278\/2015\u20104"],"award-info":[{"award-number":["306278\/2015\u20104"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["financial code 001"],"award-info":[{"award-number":["financial code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/06088\u20100"],"award-info":[{"award-number":["2018\/06088\u20100"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/07885\u20101"],"award-info":[{"award-number":["2018\/07885\u20101"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2020\/01221\u20104"],"award-info":[{"award-number":["2020\/01221\u20104"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>The SARS\u2010CoV\u20102 virus, responsible for COVID\u201019, spread rapidly worldwide and became a pandemic in 2020. In some patients, the virus remains in the respiratory tract, causing pneumonia, respiratory failure, acute respiratory distress syndrome (ARDS), and sepsis, leading to death. Natural flavonoids (aglycone and glycosides) possess broad biological activities encompassing antiinflammatory, antiviral, antitumoral, antiallergic, antiplatelet, and antioxidant effects. While many studies have focused on the effects of natural flavonoids in experimental models, reports based on clinical trials are still insufficient. In this review, we highlight the effects of flavonoids in controlling pulmonary diseases, particularly the acute respiratory distress syndrome, a consequence of COVID\u201019, and their potential use in coronavirus\u2010related diseases. Furthermore, we also focus on establishing a relationship between biological potential and chemical aspects of related flavonoids and discuss several possible mechanisms of action, pointing out some possible effects on COVID\u201019.<\/jats:p>","DOI":"10.1002\/ptr.7131","type":"journal-article","created":{"date-parts":[[2021,4,30]],"date-time":"2021-04-30T04:38:23Z","timestamp":1619757503000},"page":"4988-5006","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["New perspectives on natural flavonoids on <scp>COVID<\/scp>\u201019\u2010induced lung injuries"],"prefix":"10.1002","volume":"35","author":[{"given":"Fernanda Paula R.","family":"Santana","sequence":"first","affiliation":[{"name":"Department of Bioscience Federal University of S\u00e3o Paulo  Santos S\u00e3o Paulo Brazil"},{"name":"Department of Immunology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda","family":"Thevenard","sequence":"additional","affiliation":[{"name":"Center of Natural Sciences and Humanities Federal University of ABC  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaio S.","family":"Gomes","sequence":"additional","affiliation":[{"name":"Center of Natural Sciences and Humanities Federal University of ABC  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Taguchi","sequence":"additional","affiliation":[{"name":"Department of Bioscience Federal University of S\u00e3o Paulo  Santos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niels Olsen S.","family":"C\u00e2mara","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute of Biomedical Sciences University of S\u00e3o Paulo  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta S.","family":"Stilhano","sequence":"additional","affiliation":[{"name":"Department of Physiological Sciences Santa Casa de S\u00e3o Paulo School of Medical Sciences  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo P.","family":"Ureshino","sequence":"additional","affiliation":[{"name":"Department of Biological Science Federal University of S\u00e3o Paulo  Diadema S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla Maximo","family":"Prado","sequence":"additional","affiliation":[{"name":"Department of Bioscience Federal University of S\u00e3o Paulo  Santos S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1193-8374","authenticated-orcid":false,"given":"Jo\u00e3o Henrique Ghilardi","family":"Lago","sequence":"additional","affiliation":[{"name":"Center of Natural Sciences and Humanities Federal University of ABC  S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,4,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118167"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/35099560"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00455.2020"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1085658"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.118.017129"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.04.020"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2014.12.015"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-74715-4"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2005.01.005"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.0291"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201000080"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-020-09137-5"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00444.2015"},{"key":"e_1_2_8_15_1","first-page":"1","article-title":"Botanical drugs and supplements affecting the immune response in the time of COVID\u201019: Implications for research and clinical practice","volume":"29","author":"Brendler T.","year":"2020","journal-title":"Phytotherapy Research"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2020.108253"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/22221751.2020.1719902"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ecam\/neh081"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI137244"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2006.09.014"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa078"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2013.03.027"},{"key":"e_1_2_8_23_1","first-page":"241","article-title":"Flavonoides: Potenciais agentes terap\u00eauticos para o processo inflamat\u00f3rio","volume":"1","author":"Coutinho M. A. S.","year":"2009","journal-title":"Revista Virtual de Qu\u00edmica"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.16873"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jth.14844"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-015-0233-y"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00038.2017"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-827X(01)01111-9"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40779-020-00240-0"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2007\/45673"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1570"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-7258(02)00298-X"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2011.00065"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000078498"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.02.052"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2007.040048"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03712"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6700"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1080\/07391102.2020.1840444"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X11311020007"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12040372"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13604"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2019.1690480"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1493588"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2012.753591"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1254\/jphs.CRJ04003X"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2222.2000.00768.x"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.03.039"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa097"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2016.05.013"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2011.07.012"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6186"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules19033570"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-10-4166"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2016.05.007"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30920-X"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.06.009"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40249-020-00662-x"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature02145"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2005.07.002"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.25761"},{"key":"e_1_2_8_62_1","first-page":"1","article-title":"Inflammatory mechanisms in the lung","volume":"2","author":"Moldoveanu B.","year":"2009","journal-title":"Journal of Inflammation Research"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1107\/S1399004715003521"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10529-011-0845-8"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/74.4.418"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrfmmm.2004.01.015"},{"key":"e_1_2_8_67_1","first-page":"191","article-title":"Angiotensin metabolism in rat stomach wall: Prevalence of angiotensin\u20101\u20107 formation","volume":"60","author":"Olszanecki R.","year":"2009","journal-title":"Journal of Physiology and Pharmacology"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2020200370"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1017\/jns.2016.41"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2014.1003215"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756366.2016.1265519"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(03)13412-5"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2020.03.009"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12005"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-020-01550-6"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S31379"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102433"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2018.03.042"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109211"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.09.035"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2348968"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12985-019-1182-0"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1360277"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1159\/000508247"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.4149\/av_2018_109"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2020.03.016"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1843.2006.00861.x"},{"key":"e_1_2_8_88_1","first-page":"1","article-title":"Flavonoids: A complementary approach to conventional therapy of COVID\u201019?","author":"Solnier J.","year":"2020","journal-title":"Phytochemistry Reviews"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2012.06.009"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00217.2020"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.81624-0"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-014-9930-1"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0047403"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6781"},{"key":"e_1_2_8_95_1","first-page":"1","volume-title":"Methods in molecular biology","author":"Wang Y.","year":"2020"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2015.07.138"},{"key":"e_1_2_8_97_1","article-title":"COVID\u201019: Attacks the 1\u2010beta chain of hemoglobin and captures the porphyrin to inhibit human heme metabolism","author":"Wenzhong L.","year":"2020","journal-title":"ChemRxiv"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120156"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.11.004"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.556481"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abb2762"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinf.2020.03.037"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexmp.2019.104350"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1111\/resp.13196"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2005.46.5.585"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1211721"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.26634"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.02.081"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.202001-0179LE"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2012-7"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2015.2827"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2009.02.001"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.7131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T00:28:42Z","timestamp":1692836922000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.7131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,29]]},"references-count":111,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["10.1002\/ptr.7131"],"URL":"https:\/\/doi.org\/10.1002\/ptr.7131","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,29]]},"assertion":[{"value":"2021-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-04-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}