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This study explored the effect and mechanism of daidzein (DAI) in reducing DDP\u2010induced skeletal muscle atrophy and cachexia in vivo and in vitro. DAI alleviated the weight, food intake, muscle, adipose tissue, kidney weight and forelimb grip of LLC tumour\u2010bearing mice after DDP treatment, and did not affect the antitumour effect of DDP. DAI can reduce the decrease of the cross\u2010sectional area of skeletal muscle fibre\u2010induced by DDP and prevent the change of fibre type proportion. In skeletal muscle, it can inhibit Glut4\/AMPK\/FoxO pathway, down\u2010regulate the expression of atrogin1 and MuRF1, and inhibit skeletal muscle protein degradation. In DDP treated C2C12 myotubes, DAI could inhibit Glut4\/AMPK\/FoxO pathway to reduce myotubes atrophy, while AMPK agonist MK\u20103903 could reverse the protective effect of DAI. These results suggest that DAI can alleviate DDP\u2010induced skeletal muscle atrophy by downregulating the expression of Atrogin1 and MuRF1 through the regulation of Glut4\/AMPK\/FoxO pathway.<\/jats:p>","DOI":"10.1002\/ptr.7132","type":"journal-article","created":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T06:21:51Z","timestamp":1618899711000},"page":"4363-4376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":52,"title":["Daidzein alleviates cisplatin\u2010induced muscle atrophy by regulating Glut4\/\n                    <scp>AMPK<\/scp>\n                    \/\n                    <scp>FoxO<\/scp>\n                    pathway"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6693-694X","authenticated-orcid":false,"given":"Hong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pharmacy Shanghai Jiao Tong University Affiliated Shanghai Sixth People's 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