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Among natural products, phytosteroids have emerged as promising compounds mostly because they have diverse pharmacological activities. Currently, available medications exert numerous systemic toxicities, including hypertension, immune suppression, osteoporosis, and metabolic abnormalities. Thus, further research on phytosteroids to subside these complications is of significant importance. In this study, the information on phytosteroids, their types, and actions against inflammation, and allergic complications was collected by a systematic survey of literature on several scientific search engines. The literature review suggested that phytosteroids exhibit antiinflammatory action via different modes through transrepression or selective COX\u20102 enzymes. Also, in silico ADMET analysis was carried out on available phytosteroids to uncover their pharmacokinetic properties. Our analysis has shown that eight compounds: withaferin A, stigmasterol, \u03b2\u2010sitosterol, guggulsterone, diosgenin, sarsasapogenin, physalin A, and dioscin, \u2212isolated from medicinal plants show similar pharmacokinetic properties as compared to dexamethasone, commercially available glucocorticoid. These phytosteroids could be useful for the treatment of inflammatory diseases, such as rheumatoid arthritis, inflammatory bowel diseases, multiple sclerosis, asthma, and cardiovascular diseases. Thus, systematic research is required to explore potent phytosteroids with lesser side effects, which might substitute the current medications.<\/jats:p>","DOI":"10.1002\/ptr.7138","type":"journal-article","created":{"date-parts":[[2021,5,7]],"date-time":"2021-05-07T15:18:16Z","timestamp":1620400696000},"page":"5103-5124","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":70,"title":["Pharmacologic activities of phytosteroids in inflammatory diseases: Mechanism of action and therapeutic potentials"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9065-159X","authenticated-orcid":false,"given":"Rishab","family":"Marahatha","sequence":"first","affiliation":[{"name":"Biological Chemistry Lab, Central Department of Chemistry Tribhuvan University  Kirtipur 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