{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T19:41:10Z","timestamp":1788982870458,"version":"build-2803163510"},"reference-count":32,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:p>Erianin is a small\u2010molecule compound that is isolated from <jats:italic>Dendrobium chrysotoxum Lindl<\/jats:italic>. In recent years, it has been found to have evident antitumor activity in various cancers, such as bladder cancer, cervical cancer, and nasopharyngeal carcinoma. In this study, we assessed the effect of erianin on lung cancer in terms of cell growth inhibition and the related mechanism. First, erianin at a concentration of less than 1\u2009nmol\/L exhibited cytotoxicity in H1975, A549, LLC lung cancer cells, did not cause marked growth inhibition in normal lung and kidney cells, induced obvious apoptosis and G2\/M phase arrest of cells, and inhibited the migration and invasion of lung cancer cells in vitro. Second, in a mouse xenograft model of lewis lung cancer (LLC), oral administration of erianin (50, 35, and 10\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup> for 12\u2009days) substantially inhibited nodule growth, reduced the fluorescence counts of lewis cells and the percentage vascularity of tumor tissues, increased the number of apoptotic tumor cells, the thymus indices, up\u2010regulated the levels of interleukin (IL)\u20102 and tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), decreased IL\u201010 levels and the spleen index, and enhanced immune function. Lastly, the possible targets of erianin were determined by molecular docking and verified via western blot assay. The results indicated that erianin may achieve the above effects via inhibiting the phosphoinositide 3\u2010kinase (PI3K)\/Akt\/mammalian target of rapamycin (mTOR) pathway in vitro and vivo. Taken together, the results showed that erianin had obvious antitumor effects via inhibiting the PI3K\/Akt\/mTOR pathway in vitro and vivo and may have potential clinical value for the treatment of lung cancer.<\/jats:p>","DOI":"10.1002\/ptr.7154","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T10:04:42Z","timestamp":1625738682000},"page":"4511-4525","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Erianin inhibits human lung cancer cell growth via <scp>PI3K<\/scp>\/Akt\/<scp>mTOR<\/scp> pathway in vitro and in vivo"],"prefix":"10.1002","volume":"35","author":[{"given":"Hui\u2010qiong","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources  Chengdu China"},{"name":"School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu 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