{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T20:29:37Z","timestamp":1762374577774},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2001,3,16]],"date-time":"2001-03-16T00:00:00Z","timestamp":984700800000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2001,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Selection of an adequate placebo is a major problem in clinical trials of Euminz\u00ae (10% peppermint oil\/ethanol) which is used topically for the treatment of tension\u2010type headache. This randomized, controlled, double\u2010blind, cross\u2010over study was performed to investigate whether there are qualitative differences between 10%, 1%, 0.5%, 0.1%, and 0% peppermint oil. Forty\u2010one healthy subjects participated (age range 21\u201328 years); they rated both intensity, and hedonic tone of the stimuli. Verbal descriptions were combined to multiple response sets (MRS). In addition, the trigeminal impact of odorants was determined. Intensity ratings and MRS \u2018menthol like\u2019 and \u2018alcohol\/solvent\u2019 changed with stimulus concentration. However, intensity had no significant effect on hedonics, trigeminal impact, or the number of descriptive items used. When MRS \u2018menthol like\u2019 and \u2018alcohol\/solvent\u2019 were analysed after being weighted with intensity ratings, changes in relation to stimulus concentration were lost. Thus, the differences between the five concentrations of peppermint oil were\u2014to their largest part\u2014due to changes in stimulus intensity. Considering the large day\u2010to\u2010day variability of olfactory sensitivity the present data support the hypothesis that the odour quality of 10% peppermint oil cannot be discriminated from the odour of 0.1%, 0.5%, or 1% peppermint oil when tested on separate days. Copyright \u00a9 2001 John Wiley &amp; Sons, Ltd.<\/jats:p>","DOI":"10.1002\/ptr.716","type":"journal-article","created":{"date-parts":[[2002,8,25]],"date-time":"2002-08-25T21:44:55Z","timestamp":1030311895000},"page":"135-138","source":"Crossref","is-referenced-by-count":29,"title":["Qualitative and quantitative olfactometric evaluation of different concentrations of ethanol peppermint oil solutions"],"prefix":"10.1002","volume":"15","author":[{"given":"D.","family":"Krone","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Mannel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Pauli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Hummel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2001,3,16]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"587","article-title":"Trigeminal impact of odorants assessed with lateralized stimulation","volume":"23","author":"Berg J","year":"1998","journal-title":"Chem Senses"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9384(85)90200-8"},{"key":"e_1_2_1_4_1","first-page":"377","volume-title":"Clinical Measurement of Taste and Smell","author":"Doty RL","year":"1986"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/00022470.1984.10465810"},{"key":"e_1_2_1_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0013-4694(95)00055-4"},{"key":"e_1_2_1_7_1","first-page":"169","volume-title":"Headache\u2010Treatment: Trial Methodology and New Drugs","author":"G\u00f6bel H","year":"1997"},{"key":"e_1_2_1_8_1","first-page":"452","article-title":"Efficacy of oleum menthae piperitae versus acetylsalicylic acid in tension\u2010type headache","volume":"19","author":"G\u00f6bel H","year":"1999","journal-title":"Cephalalgia"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01958823"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/17.1.13"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.1.39"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199801000-00021"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050223"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01954845"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/22.5.593"},{"key":"e_1_2_1_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/chemse\/13.4.643"},{"key":"e_1_2_1_17_1","first-page":"69","article-title":"\u00dcber die Lokalisation der Empfindungen bei den niederen Sinnen","volume":"56","author":"von Skramlik E","year":"1924","journal-title":"Z Sinnesphysiol"},{"key":"e_1_2_1_18_1","first-page":"39","volume-title":"Die Naturgeschichte des Cajus Plinius Secundus","author":"Wittstein GC","year":"1881"},{"key":"e_1_2_1_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)01276-1"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fptr.716","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.716","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T09:31:27Z","timestamp":1700299887000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.716"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2001,3]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2001,3]]}},"alternative-id":["10.1002\/ptr.716"],"URL":"https:\/\/doi.org\/10.1002\/ptr.716","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2001,3]]}}}