{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:52:52Z","timestamp":1786978372149,"version":"build-2736575974"},"reference-count":30,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T00:00:00Z","timestamp":1628640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>\n                    Osteoarthritis is the most common cause of disability and aging is the major risk factor. One of the low\u2010risk herbal medicines for reducing pain and inflammation in persian medicine is\n                    <jats:italic>Pistacia atlantica<\/jats:italic>\n                    gum. A triple\u2010blind placebo\u2010controlled clinical trial was performed in order to evaluate the efficacy of\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>atlantica<\/jats:italic>\n                    gum ointment on knee osteoarthritis in elderly people. A total of 60 patients were randomly allocated to two groups. The intervention group used 4%\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>atlantica<\/jats:italic>\n                    ointment and the control group used placebo, topically applied three times a day, for 8\u2009weeks. The patients were evaluated before and after the intervention using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scale. There were significant differences (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001) between two the groups in terms of joint stiffness and pain as well as function. Within groups, regarding the effect size (EF) in joint stiffness was 2.82 and 0.74 in the\n                    <jats:italic>Pistacia<\/jats:italic>\n                    and placebo groups, respectively. Regarding pain, the effect size of the intervention and placebo groups were 3.90 and 0.99, respectively. In addition, regarding function, the effect size of the intervention and the placebo groups were 4.33 and 1.17, respectively. Therefore, it seems that topical\n                    <jats:italic>P<\/jats:italic>\n                    .\n                    <jats:italic>atlantica<\/jats:italic>\n                    is significantly better than the placebo in the old patients with knee osteoarthritis.\n                  <\/jats:p>","DOI":"10.1002\/ptr.7178","type":"journal-article","created":{"date-parts":[[2021,8,11]],"date-time":"2021-08-11T03:46:51Z","timestamp":1628653611000},"page":"5125-5132","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Effectiveness of\n                    <scp>\n                      <i>Pistacia atlantica<\/i>\n                    <\/scp>\n                    on older adult knee osteoarthritis, a randomized triple blind clinical trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Ali","family":"Khamevar","sequence":"first","affiliation":[{"name":"Department of Traditional Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Traditional and Complementary Medicine Research Center, Addiction Institute, Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Ali","family":"Ebrahimzadeh","sequence":"additional","affiliation":[{"name":"Department of Medicinal Chemistry, School of Pharmacy Traditional and Complementary Medicine Research Center, Addiction Research Institutes, Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahmood","family":"Moosazadeh","sequence":"additional","affiliation":[{"name":"Non\u2010communicable Diseases Institute, Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masoud","family":"Shayesteh Azar","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, School of Medicine Orthopedic Research Center, Sari Imam Khomeini Hospital, Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Saeedi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy Pharmaceutical Sciences Research Center, Hemoglobinopathy Research Institute, Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adel","family":"Bakhtiary Far","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutics, School of Pharmacy Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0204-0837","authenticated-orcid":false,"given":"Seyde Sedighe","family":"Yousefi","sequence":"additional","affiliation":[{"name":"Department of Traditional Persian Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,11]]},"reference":[{"key":"e_1_2_11_2_1","volume-title":"Makhzan Al\u2010adviyah (the storehouse of medicaments)","author":"Alavi S.","year":"2009"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(200111)44:11<2531::AID-ART433>3.0.CO;2-J"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.22038\/ajp.2017.22182.1827"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.08.017"},{"key":"e_1_2_11_6_1","volume-title":"Canon of medicine complete five volume set","author":"Avicenna H.","year":"2015"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctcp.2018.06.002"},{"issue":"12","key":"e_1_2_11_8_1","first-page":"2473","article-title":"WOMAC: A 20\u2010year experiential review of a patient\u2010centered self\u2010reported health status questionnaire","volume":"29","author":"Bellamy N.","year":"2002","journal-title":"The Journal of Rheumatology"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(11)60243-2"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/219815"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.22038\/abjs.2014.2373"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-010-8885-9"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-323-31696-5.00069-3"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1756-185X.2011.01615.x"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1515\/jcim-2018-0101"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2013.08.031"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570163817666200316105658"},{"key":"e_1_2_11_18_1","volume-title":"Harrison's principles of internal medicine","author":"Kasper D. 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