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Chemotherapy for schistosomiasis relies exclusively on praziquantel (PZQ). Previous studies have shown that licarin A (LIC\u2010A), a dihydrobenzofuran neolignan, exhibited in vitro antiparasitic activity against <jats:italic>Schistosoma mansoni<\/jats:italic> adult worms. This study aimed to investigate the potential of LIC\u2010A, isolated as main metabolite from leaves of <jats:italic>Nectandra oppositifolia<\/jats:italic> Nees &amp; Mart. (Lauraceae), as an antischistosomal agent orally active in schistosomiasis animal model. PZQ was used as a reference compound. As result, LIC\u2010A showed, at a single dose of 400\u2009mg\/kg, to be able to partially cure infected mice (worm burden reductions of ~50%). Parasite eggs, that are responsible for a variety of pathologies and transmission of schistosomiasis, were also moderately inhibited by LIC\u2010A (egg burden reductions of ~50%\u201360%). Furthermore, it was observed that LIC\u2010A achieved a slight reduction of hepatomegaly and splenomegaly. Collectively, although LIC\u2010A was partially active when administered orally, these results give support for the antiparasitic potential LIC\u2010A as lead compound for novel antischistosomal agent.<\/jats:p>","DOI":"10.1002\/ptr.7184","type":"journal-article","created":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T13:20:49Z","timestamp":1622899249000},"page":"5154-5162","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Licarin A, a neolignan isolated from <i>Nectandra oppositifolia<\/i> Nees &amp; Mart. 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