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A literature review on herbal medicine and commercial products in the global market showed that curcumin (Cur) has many therapeutic benefits compared to other natural ingredients. Despite the unique properties of Cur, its use in clinical trials is very limited. The poor biopharmaceutical properties of Cur such as short half\u2010life in plasma, low bioavailability, poor absorption, rapid metabolism, very low solubility (at acidic and physiological pH), and the chemical instability in body fluids are major concerns associated with the clinical applications of Cur. Recently, nanoformulations are emerging as approaches to develop and improve the therapeutic efficacy of various drugs. Many studies have shown that Cur nanoformulations have tremendous therapeutic potential against various diseases such as SARS\u2010CoV\u20102, cancer, inflammatory, osteoporosis, and so on. These nanoformulations can inhibit many diseases through several cellular and molecular mechanisms. 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The present review aims to update and explain the therapeutic potential of Cur nanoformulations.<\/jats:p>","DOI":"10.1002\/ptr.7190","type":"journal-article","created":{"date-parts":[[2021,6,16]],"date-time":"2021-06-16T06:54:55Z","timestamp":1623826495000},"page":"5527-5563","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["A comprehensive review of the therapeutic potential of curcumin nanoformulations"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4671-985X","authenticated-orcid":false,"given":"Khadijeh","family":"Khezri","sequence":"first","affiliation":[{"name":"Deputy of Food and Drug Administration Urmia University of Medical Sciences Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Majid","family":"Saeedi","sequence":"additional","affiliation":[{"name":"Pharmaceutical Sciences Research Center, Hemoglobinopathy Institute, Mazandaran University of Medical Sciences Sari Iran"},{"name":"Department of Pharmaceutics, Faculty of Pharmacy Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hassan","family":"Mohammadamini","sequence":"additional","affiliation":[{"name":"Khoy University of Medical Sciences Khoy Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas Seyed","family":"Zakaryaei","sequence":"additional","affiliation":[{"name":"Urmia University of Medical Sciences Urmia Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,6,15]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.2174\/1871530319666190212170140"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00251-017-0992-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119835"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110688"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3109\/21691401.2015.1129628"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.14282"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00288-2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2011.01002.x"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.02.025"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.03.027"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.01.047"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3050"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2019.11.008"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00709-013-0516-9"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-018-0606-7"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1166\/jbn.2017.2372"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-11-52"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biotechadv.2011.05.009"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12668-021-00842-5"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/1559325818790869"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2016.060"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2018.09.001"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23016"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.102020"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2019.125933"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102360"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-010-9042-7"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2020.111263"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13779"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.4103\/0250-474X.44591"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tifs.2017.11.009"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ejp.620"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.03.101"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcph.806"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78241-1"},{"issue":"3","key":"e_1_2_8_37_1","first-page":"868","article-title":"Anticancer activity of curcumin\u2010loaded PLGA nanoparticles on PC3 prostate cancer cells","volume":"16","author":"Azandeh S. 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