{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:42:56Z","timestamp":1790700176065,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T00:00:00Z","timestamp":1626134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,9]]},"abstract":"<jats:p>This double\u2010blind randomized clinical trial aimed to investigate impact of <jats:italic>Cornus mas<\/jats:italic> L. fruit extract (CMFE) on liver function in nonalcoholic fatty liver disease (NAFLD). Fifty patients were randomly assigned into the CMFE and placebo groups to receive 20\u2009ml of the extract or placebo for 12\u2009weeks, respectively. Serum alanine aminotransferase, aspartate aminotransferase, cytokeratin 18 (CK\u201018) levels, and steatosis and fibrosis scores were examined before and after the intervention. Although, a significant decrease was observed in CK\u201018 levels among the CMFE group (288.80\u2009\u00b1\u200985.40 vs. 235.66\u2009\u00b1\u200960.38; <jats:italic>p<\/jats:italic>\u00a0=\u00a0.001) after 12\u2009weeks, no significant difference was found between the two groups. Moreover, a significant increase in fibrosis score in the placebo group (8.20 (6.35\u20139.40) vs. 8.40 (7.70\u201313.00); <jats:italic>p<\/jats:italic>\u00a0=\u2009.03) as well as a significant difference in this marker (CMEF: 7.64 (6.30\u20138.25); placebo: 8.40 (7.70\u201313.00); <jats:italic>p<\/jats:italic>\u00a0=\u2009.02) and its changes (CMEF: 0.60 (\u22121.00\u20131.07); placebo: 0.80 (\u22120.25\u20133.95); <jats:italic>p<\/jats:italic>\u00a0=\u2009.02) were found between the groups after 12\u2009weeks. No significant effect was noted on other variables. Therefore, consuming CMFE might have some beneficial effects on liver function markers in NAFLD. However, more studies are required in this area.<\/jats:p>","DOI":"10.1002\/ptr.7199","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T07:19:23Z","timestamp":1626160763000},"page":"5259-5268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["The effect of (<scp><i>Cornus mas<\/i><\/scp> L.) fruit extract on liver function among patients with nonalcoholic fatty liver: A double\u2010blind randomized clinical trial"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8185-4558","authenticated-orcid":false,"given":"Zohreh Sadat","family":"Sangsefidi","sequence":"first","affiliation":[{"name":"Department of Nutrition, School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"},{"name":"Nutrition and Food Security Research Center Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faezeh","family":"Yarhosseini","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"},{"name":"Nutrition and Food Security Research Center Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7482-2494","authenticated-orcid":false,"given":"Mahdieh","family":"Hosseinzadeh","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"},{"name":"Nutrition and Food Security Research Center Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2679-7041","authenticated-orcid":false,"given":"Alimohammad","family":"Ranjbar","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, Faculty of Pharmacy Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohsen","family":"Akhondi\u2010Meybodi","sequence":"additional","affiliation":[{"name":"Gastroentrology Department, Shahid Sadoughi Hospital, Faculty of Medicine Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hossein","family":"Fallahzadeh","sequence":"additional","affiliation":[{"name":"Research Center of Prevention and Epidemiology of Non\u2010Communicable Disease, Department of Biostatistics and Epidemiology, School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3513-1778","authenticated-orcid":false,"given":"Hassan","family":"Mozaffari\u2010Khosravi","sequence":"additional","affiliation":[{"name":"Department of Nutrition, School of Public Health Shahid Sadoughi University of Medical Sciences  Yazd Iran"},{"name":"Nutrition and Food Security Research Center Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,13]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"250","article-title":"Effects of hydro\u2010methanolic extract of Cornus mas on histopathological and biochemical parameters of rats' liver and kidney","volume":"44","author":"Abbasi M. 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