{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:08Z","timestamp":1786978388185,"version":"build-2736575974"},"reference-count":45,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T00:00:00Z","timestamp":1625184000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>This study aims to evaluate the clinical efficacy of curcumin versus chlorhexidine as adjuncts to scaling and root planing (SRP) for periodontitis treatment. We searched PubMed, EMbase, Cochrane Library, and ClinicalTrials.gov from inception to February 18, 2021 and identified studies with relevant randomized controlled trials (RCTs) using curcumin or chlorhexidine as an adjunct to SRP. Nine RCTs involving 420 patients\/sites were included. A meta\u2010analysis with a random\u2010effects model revealed that curcumin and chlorhexidine, as an adjunct to SRP, reduced probing pocket depth (PPD) at similar levels during a 3\u2010, 4\u2010, 6\u2010, and 12\u2010week follow\u2010up. No significant differences were observed in reducing clinical attachment loss (CAL) between curcumin and chlorhexidine as an adjunct to SRP at 4\u2009weeks and 6\u2009weeks. Furthermore, gingival index (GI) and plaque index (PI) were similar using curcumin versus chlorhexidine as an adjunct to SRP at the 4\u2010week\u2010, 6\u2010week\u2010, and 12\u2010week follow\u2010up. Based on the available evidence in RCTs, compared with chlorhexidine as an adjunct to SRP, curcumin has a similar effect on reducing PPD, CAL, GI, and PI. The quality of evidence is low, limited by the number of studies and their limitations. Further studies are needed to firmly establish the clinical efficacy of curcumin.<\/jats:p>","DOI":"10.1002\/ptr.7208","type":"journal-article","created":{"date-parts":[[2021,7,3]],"date-time":"2021-07-03T03:18:34Z","timestamp":1625282314000},"page":"5980-5991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Clinical efficacy of curcumin versus chlorhexidine as an adjunct to scaling and root planing for the treatment of periodontitis: A systematic review and meta\u2010analysis"],"prefix":"10.1002","volume":"35","author":[{"given":"Yang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Periodical Press and National Clinical Research Center for Geriatrics, West China Hospital Sichuan University  Chengdu China"},{"name":"Chinese Evidence\u2010Based Medicine Center, West China Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Huang","sequence":"additional","affiliation":[{"name":"West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danuta","family":"Mazurel","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanhua","family":"Zheng","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease &amp; National Clinical Research Center for Oral Disease, Department of Periodontics, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4318-9283","authenticated-orcid":false,"given":"Jingmei","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Oral Disease &amp; National Clinical Research Center for Oral Disease, Department of Periodontics, West China Hospital of Stomatology Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongmei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam University of Amsterdam and Vrije Universiteit Amsterdam  Amsterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,2]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.b19-00699"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9290.156806"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nux047"},{"issue":"7","key":"e_1_2_9_5_1","first-page":"5299","article-title":"Comparative evaluation of efficacy of sub\u2010gingivally delivered 2% indigenously prepared curcumin gel and 1% commercially available hexigel as an adjunct to scaling and root planing in chronic periodontitis patients: A split mouth randomized controlled clinical trial","volume":"7","author":"Desai A.","year":"2020","journal-title":"European Journal of Molecular & Clinical Medicine"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2012.110664"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1902\/annals.1999.4.1.32"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0976-237x.114874"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/jisp.jisp_207_19"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.39489.470347.AD"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-020-03090-3"},{"key":"e_1_2_9_12_1","doi-asserted-by":"crossref","unstructured":"Higgins J. 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