{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:14:40Z","timestamp":1791587680155,"version":"4.3.4"},"reference-count":152,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T00:00:00Z","timestamp":1625702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Marijuana, or <jats:italic>Cannabis sativa<\/jats:italic> L., is a common psychoactive plant used for both recreational and medicinal purposes. In many countries, cannabis\u2010based medicines have been legalized under certain conditions because of their immense prospects in medicinal applications. With a comprehensive insight into the prospects and challenges associated with the pharmacological use and global trade of <jats:italic>C. sativa<\/jats:italic>, this mini\u2010review focuses on the medicinal importance of the plant and its legal status worldwide; the pharmacological compounds and its therapeutic potential along with the underlying public health concerns and future perspective are herein discussed. The existence of major compounds including \u0394<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol (\u0394<jats:sup>9<\/jats:sup>\u2010THC), cannabidiol, cannabinol, and cannabichromene contributes to the medicinal effects of the cannabis plant. These compounds are also involved in the treatment of various types of cancer, epilepsy, and Parkinson's disease displaying several mechanisms of action. <jats:italic>Cannabis sativa<\/jats:italic> is a plant with significant pharmacological potential. However, several aspects of the plant need an in\u2010depth understanding of the drug mechanism and its interaction with other drugs. Only after addressing these health concerns, legalization of <jats:italic>cannabis<\/jats:italic> could be utilized to its full potential as a future medicine.<\/jats:p>","DOI":"10.1002\/ptr.7213","type":"journal-article","created":{"date-parts":[[2021,7,8]],"date-time":"2021-07-08T23:59:43Z","timestamp":1625788783000},"page":"6010-6029","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":102,"title":["Pharmacological properties, therapeutic potential, and legal status of <scp><i>Cannabis sativa<\/i><\/scp> L.: An overview"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0892-5425","authenticated-orcid":false,"given":"Pradeep","family":"Kumar","sequence":"first","affiliation":[{"name":"Applied Microbiology Laboratory, Department of Forestry North Eastern Regional Institute of Science and Technology  Nirjuli India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8857-2326","authenticated-orcid":false,"given":"Dipendra Kumar","family":"Mahato","sequence":"additional","affiliation":[{"name":"CASS Food Research Centre, School of Exercise and Nutrition Sciences Deakin University  Burwood Victoria Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhu","family":"Kamle","sequence":"additional","affiliation":[{"name":"Applied Microbiology Laboratory, Department of Forestry North Eastern Regional Institute of Science and Technology  Nirjuli India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rituraj","family":"Borah","sequence":"additional","affiliation":[{"name":"Applied Microbiology Laboratory, Department of Forestry North Eastern Regional Institute of Science and Technology  Nirjuli India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bharti","family":"Sharma","sequence":"additional","affiliation":[{"name":"Department of Dairy Science and Food Technology, Institute of Agricultural Sciences Banaras Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shikha","family":"Pandhi","sequence":"additional","affiliation":[{"name":"Department of Dairy Science and Food Technology, Institute of Agricultural Sciences Banaras Hindu University  Varanasi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vijay","family":"Tripathi","sequence":"additional","affiliation":[{"name":"Department of Molecular and Cellular Engineering Jacob Institute of Biotechnology and Bioengineering, Sam Higginbottom University of Agriculture Technology and Sciences  Prayagraj India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hardeo Singh","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Chemistry North Eastern Regional Institute of Science and Technology  Nirjuli India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheetal","family":"Devi","sequence":"additional","affiliation":[{"name":"Department of Food Science and Technology National Institute of Food Technology Entrepreneurship and Management (NIFTEM)  Sonipat India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umesh","family":"Patil","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine University of Macau  Taipa Macau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianbo","family":"Xiao","sequence":"additional","affiliation":[{"name":"Institute of Chinese Medical Sciences, State Key Laboratory of Quality Research in Chinese Medicine University of Macau  Taipa Macau"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Awdhesh Kumar","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Yeungnam University  Gyeongsan South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,8]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-3908"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.01.001"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.1996.911115852.x"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf60198a007"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ypmed.2007.04.012"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addbeh.2011.07.005"},{"key":"e_1_2_13_8_1","unstructured":"Aguilar S. Guti\u00e9rrez V. S\u00e1nchez L. &Nougier M.(2018).Medicinal cannabis policies and practices around the world. IDPC Brief. Paper. International Drug Policy Consortium."},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2004.6.3\/galexander"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2006.02.001"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2016.00019"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13779"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986711794940888"},{"key":"e_1_2_13_14_1","unstructured":"Aryal N. &Adhikari R.(2019).Cannabis in Nepal and scopes of its re\u2010legalization. Conference Proceedings."},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sajb.2018.07.022"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-1110-1045"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13114"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2015.3229"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/03008880802283664"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.09.004"},{"key":"e_1_2_13_21_1","unstructured":"Bouquet J.(1912).Contribution \u00e0 l'\u00e9tude du chanvre Indien. Universit\u00e9 de Lyon."},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00108"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0215(20000415)86:2<289::AID-IJC21>3.0.CO;2-M"},{"key":"e_1_2_13_24_1","first-page":"180","article-title":"Medicinal cannabis: History, pharmacology, and implications for the acute care setting","volume":"42","author":"Bridgeman M. B.","year":"2017","journal-title":"Pharmacology and Therapeutics"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4892(02)00011-5"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-019-04774-5"},{"key":"e_1_2_13_27_1","first-page":"279","volume-title":"Pharmacognosy, phytochemistry, medicinal plants","author":"Bruneton J.","year":"1999"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-009-9084-5"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpba.2017.11.073"},{"key":"e_1_2_13_30_1","doi-asserted-by":"crossref","unstructured":"Casano S. Grassi G. Martini V. &Michelozzi M.(2010).Variations in Terpene profiles of different strains ofCannabis sativaL. Paper presented at: XXVIII International Horticultural Congress on Science and Horticulture for People (IHC2010): A New Look at Medicinal and 925).115\u2013121.","DOI":"10.17660\/ActaHortic.2011.925.15"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1080\/00952990.2019.1611840"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joim.2018.07.005"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8339.1979.tb01517.x"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jes.2019.04.028"},{"issue":"2009","key":"e_1_2_13_35_1","first-page":"1","article-title":"Translational investigation of the therapeutic potential of cannabidiol (CBD): Toward a new age","volume":"9","author":"Crippa J. A.","year":"2018","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881110379283"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-019-00982-6"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2016.28"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.17305\/bjbms.2018.3532"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2019.106635"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq096"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molonc.2014.12.010"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1159\/000495582"},{"key":"e_1_2_13_44_1","volume-title":"Chemical constituents of cannabis","author":"Elsohly M. A.","year":"2002"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-45541-9_1"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600670135"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.4781"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.4137\/PMC.S14459"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsinfecdis.9b00419"},{"key":"e_1_2_13_50_1","unstructured":"Flores Sanchez I. J.(2008).Polyketide synthases in Cannabis sativa L. Pharmacognosy department section of metabolomics Institute of Biology \u2026."},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11101-008-9094-4"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lwt.2020.109149"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1001\/archgenpsychiatry.2008.519"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.08.001"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/73171"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0216556"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smrv.2014.02.005"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules191118781"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/14651858"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2015.03.017"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2020.03.087"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1177\/002580240104100413"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1188"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/add.14640"},{"key":"e_1_2_13_65_1","volume-title":"Nutraceuticals, efficacy, safety and toxicity: Cannabis sativa and hemp","author":"Hartsel J. A.","year":"2016"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474124.2017.1292851"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.07.014"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-45968-0_17"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajme.2014.02.003"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.3345\/kjp.2015.58.11.407"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2009.07.006"},{"key":"e_1_2_13_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2009.03.008"},{"key":"e_1_2_13_73_1","first-page":"573","volume-title":"Handbook of Experimental Pharmacology","author":"Izzo A. A.","year":"2005"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5591"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2009.12.005"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15054"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-0650"},{"key":"e_1_2_13_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69421-0"},{"key":"e_1_2_13_79_1","doi-asserted-by":"publisher","DOI":"10.1097\/MCP.0000000000000026"},{"key":"e_1_2_13_80_1","doi-asserted-by":"publisher","DOI":"10.1155\/2001\/469629"},{"key":"e_1_2_13_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1711351114"},{"key":"e_1_2_13_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20071673"},{"key":"e_1_2_13_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mrrev.2008.03.002"},{"key":"e_1_2_13_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00361"},{"key":"e_1_2_13_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.105302"},{"key":"e_1_2_13_86_1","doi-asserted-by":"publisher","DOI":"10.1086\/337229"},{"key":"e_1_2_13_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(00)75003-9"},{"key":"e_1_2_13_88_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.105247"},{"key":"e_1_2_13_89_1","doi-asserted-by":"publisher","DOI":"10.1080\/02791072.2012.684624"},{"key":"e_1_2_13_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.12610"},{"key":"e_1_2_13_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.01.004"},{"key":"e_1_2_13_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-0691.2011.03570.x"},{"key":"e_1_2_13_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbior.2020.100774"},{"key":"e_1_2_13_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07205"},{"key":"e_1_2_13_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chroma.2014.10.045"},{"key":"e_1_2_13_96_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10060900"},{"key":"e_1_2_13_97_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1177-4"},{"key":"e_1_2_13_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.02.034"},{"key":"e_1_2_13_99_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600630144"},{"key":"e_1_2_13_100_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0915-2550"},{"key":"e_1_2_13_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12803"},{"key":"e_1_2_13_102_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X11666131204235805"},{"key":"e_1_2_13_103_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.indcrop.2019.05.032"},{"key":"e_1_2_13_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2013.04.034"},{"key":"e_1_2_13_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-014-0301-2"},{"key":"e_1_2_13_106_1","doi-asserted-by":"publisher","DOI":"10.1615\/CritRevEukaryotGeneExpr.2018021528"},{"key":"e_1_2_13_107_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb1924.24.670"},{"key":"e_1_2_13_108_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/1691428"},{"key":"e_1_2_13_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2008.00048.x"},{"key":"e_1_2_13_110_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867324666170810164636"},{"key":"e_1_2_13_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/np900067k"},{"key":"e_1_2_13_112_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-198184"},{"key":"e_1_2_13_113_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-12-0335"},{"key":"e_1_2_13_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2009.11.007"},{"key":"e_1_2_13_115_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-010-0219-2"},{"key":"e_1_2_13_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30406-X"},{"key":"e_1_2_13_117_1","unstructured":"Rodner Sznitman S. Olsson B. &Room R.(2008).A cannabis reader: Global issues and local experiences. Office for Official Publications of the European Communities."},{"key":"e_1_2_13_118_1","doi-asserted-by":"publisher","DOI":"10.1021\/np960004a"},{"key":"e_1_2_13_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/pca.809"},{"key":"e_1_2_13_120_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1095-8339.2005.00417.x"},{"key":"e_1_2_13_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25184078"},{"key":"e_1_2_13_122_1","first-page":"67","volume-title":"Advances in pharmacology","author":"Russo E. B.","year":"2017"},{"key":"e_1_2_13_123_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2017.0028"},{"key":"e_1_2_13_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(94)00773-M"},{"key":"e_1_2_13_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-9422(00)98242-6"},{"key":"e_1_2_13_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2013.03.004"},{"key":"e_1_2_13_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1360-0443.1992.tb02733.x"},{"key":"e_1_2_13_128_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-1100"},{"key":"e_1_2_13_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.2600601232"},{"key":"e_1_2_13_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(75)85135-1"},{"key":"e_1_2_13_131_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557516666161004162133"},{"key":"e_1_2_13_132_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2017.0002"},{"key":"e_1_2_13_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11912-019-0757-7"},{"key":"e_1_2_13_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2018.07.020"},{"key":"e_1_2_13_135_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2020.1795129"},{"key":"e_1_2_13_136_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-11-0124"},{"key":"e_1_2_13_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2014.08.060"},{"key":"e_1_2_13_138_1","volume-title":"The analytical chemistry of cannabis: Quality assessment, assurance, and regulation of medicinal marijuana and cannabinoid preparations","author":"Thomas B. F.","year":"2015"},{"key":"e_1_2_13_139_1","doi-asserted-by":"publisher","DOI":"10.1080\/10790268.2020.1865709"},{"key":"e_1_2_13_140_1","unstructured":"UN. (1977).United Nations conference for the adoption of a protocol on psychotropic substances. Convention on psychotropic substances 1971: Including final act and resolutions as agreed by the 1971 United Nations conference for the adoption of a protocol on psychotropic substances and the schedules annexed to the convention. New York: United Nations."},{"key":"e_1_2_13_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.07.048"},{"key":"e_1_2_13_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2019.01.003"},{"key":"e_1_2_13_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800756-3.00114-9"},{"key":"e_1_2_13_144_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1402309"},{"issue":"1","key":"e_1_2_13_145_1","first-page":"85","article-title":"Delta (9)\u2010tetrahydrocannabinol inhibits 17\u03b2\u2010estradiol\u2010induced proliferation and fails to activate androgen and estrogen receptors in MCF7 human breast cancer cells","volume":"28","author":"Von Bueren A. O.","year":"2008","journal-title":"Anticancer Research"},{"key":"e_1_2_13_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-60952-0"},{"key":"e_1_2_13_147_1","doi-asserted-by":"publisher","DOI":"10.1002\/fsn3.1976"},{"key":"e_1_2_13_148_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0215(20001015)88:2<239::AID-IJC15>3.0.CO;2-Z"},{"key":"e_1_2_13_149_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.5b05282"},{"key":"e_1_2_13_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phytol.2016.09.001"},{"key":"e_1_2_13_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2010.100"},{"key":"e_1_2_13_152_1","doi-asserted-by":"publisher","DOI":"10.3897\/pharmacia.67.e51304"},{"key":"e_1_2_13_153_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1516-44462006000200015"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7213","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.7213","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T23:54:35Z","timestamp":1692834875000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.7213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,8]]},"references-count":152,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["10.1002\/ptr.7213"],"URL":"https:\/\/doi.org\/10.1002\/ptr.7213","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,8]]},"assertion":[{"value":"2020-12-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-08","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}