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Currently, in addition to the use of related pharmacological treatments in the management of CVDs, the investigation of other suitable healthcare approaches for these disorders such as the identification of herbal medicines has been considered in the scientific communities. <jats:italic>Aloe vera<\/jats:italic> (L.) Burm.f. is a perennial medicinal plant. The innermost leaf layer of this plant contains transparent gel, which is used as food. Pre\u2010clinical studies have shown several biological activities of <jats:italic>A. vera<\/jats:italic> gel (AVG), including antidiabetic, lipid\u2010lowering, antioxidant, antiinflammatory, hepatoprotective, and immunomodulatory effects. Other pharmacological activities of AVG such as anti\u2010fibrotic, anti\u2010hypertensive, and anti\u2010atherosclerotic effects have been reported. Moreover, several clinical studies have demonstrated the ameliorating effects of AVG on some markers of CVDs risk factors. Thus, this study was conducted to review clinical trials besides in vitro and in vivo studies on the cardiac beneficial effects of AVG. However, further high\u2010quality studies are needed to firmly establish the clinical efficacy of the plant.<\/jats:p>","DOI":"10.1002\/ptr.7219","type":"journal-article","created":{"date-parts":[[2021,8,6]],"date-time":"2021-08-06T05:40:44Z","timestamp":1628228444000},"page":"6101-6113","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Potential protective effects of <scp><i>Aloe vera<\/i><\/scp> gel on cardiovascular diseases: A mini\u2010review"],"prefix":"10.1002","volume":"35","author":[{"given":"Saeideh","family":"Sabbaghzadegan","sequence":"first","affiliation":[{"name":"School of Persian Medicine Iran University of Medical Sciences  Tehran Iran"},{"name":"Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haide","family":"Golsorkhi","sequence":"additional","affiliation":[{"name":"School of Persian Medicine Iran University of Medical Sciences  Tehran Iran"},{"name":"Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1739-7393","authenticated-orcid":false,"given":"Mohammad Hossein","family":"Soltani","sequence":"additional","affiliation":[{"name":"Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical Sciences  Yazd Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Kamalinejad","sequence":"additional","affiliation":[{"name":"Department of Pharmacognosy, School of Pharmacy Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6567-3749","authenticated-orcid":false,"given":"Mohsen","family":"Bahrami","sequence":"additional","affiliation":[{"name":"Private Clinic  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9496-4705","authenticated-orcid":false,"given":"Ali","family":"Kabir","sequence":"additional","affiliation":[{"name":"Minimally Invasive Surgery Research Center Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-8648","authenticated-orcid":false,"given":"Majid","family":"Dadmehr","sequence":"additional","affiliation":[{"name":"School of Persian Medicine Iran University of Medical Sciences  Tehran Iran"},{"name":"Research Institute for Islamic and Complementary Medicine, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,8,5]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000331978503600801"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13197-011-0229-z"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2016.09.096"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oooo.2013.08.003"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13779"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12463"},{"issue":"1","key":"e_1_2_10_8_1","first-page":"40","article-title":"Trends on the treatment of atherosclerosis; new improvements","volume":"1","author":"Asadi\u2010Samani M.","year":"2016","journal-title":"Angiologica Persica Acta"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6776"},{"issue":"2","key":"e_1_2_10_10_1","first-page":"832","article-title":"Anti\u2010inflammatory and immunomodulatory activity of ethanol extract of Aloe vera gel","volume":"9","author":"Bhalsinge R.","year":"2018","journal-title":"International Journal of Pharmaceutical Sciences Research"},{"issue":"1","key":"e_1_2_10_11_1","first-page":"48","article-title":"Effect of Aloe vera (L.) 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