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Total 270 eligible women were randomized to either one of the three isocaloric supplements: 40\u2009g soy flour (whole soy group), 40\u2009g low\u2010fat milk powder\u2009+63\u2009mg daidzein (daidzein group) or 40\u2009g low\u2010fat milk powder (placebo) daily for 6\u00a0months. Serum thyroid markers were tested at baseline and 6\u00a0months for thyroid stimulating hormone, free triiodothyronine, reverse triiodothyronine and free thyroxine (FT4). There was no significant difference in the 6\u2010month changes of thyroid markers among the three groups. Subgroup analysis among women with lowered thyroid function suggested a modest decrease of FT4. This randomized controlled trial among Chinese equol\u2010producing postmenopausal women indicates the consumption of whole soy and purified daidzein at the provided dosages are safe and have no detrimental effect on thyroid function.<\/jats:p>","DOI":"10.1002\/ptr.7244","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T05:03:10Z","timestamp":1631077390000},"page":"5838-5846","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The 6\u2010month effect of whole soy and purified isoflavones daidzein on thyroid <scp>function<\/scp><b>\u2014<\/b><scp>A<\/scp> double\u2010blind, randomized, placebo controlled trial among Chinese equol\u2010producing postmenopausal women"],"prefix":"10.1002","volume":"35","author":[{"given":"Zhao\u2010min","family":"Liu","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, 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