{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:40:39Z","timestamp":1788234039726,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T00:00:00Z","timestamp":1631059200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100005001","name":"Ahvaz Jundishapur University of Medical Sciences","doi-asserted-by":"publisher","award":["NRC\u20109811"],"award-info":[{"award-number":["NRC\u20109811"]}],"id":[{"id":"10.13039\/501100005001","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:p>\n                    Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. The beneficial effects of pomegranate have been shown on insulin resistance and obesity, which are linked to NAFLD pathogenesis. The aim of this study was to investigate the efficacy of pomegranate extract in patients with NAFLD. Forty\u2010four NAFLD patients were randomly assigned to receive two pomegranate extract tablets or placebo for 12\u2009weeks. Anthropometric measurements, serum lipids, glycemic indicators, and blood pressure were assessed at baseline and the end of the study. Pomegranate was associated with a reduction in the total cholesterol (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u02c2\u00a0.001), triglyceride (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u02c2\u00a0.001), low\u2010density lipoprotein cholesterol (LDL\u2010C)\u2010to\u2010high\u2010density lipoprotein cholesterol (HDL\u2010C) ratio (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u02c2\u00a0.003), fasting blood sugar (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u02c2\u00a0.001), homeostatic model assessment of insulin resistance (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.02), diastolic blood pressure (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.04), weight (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u02c2\u00a0.001), body mass index (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u02c2\u00a0.001), and waist circumference (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u00a0.002), as compared to placebo. A significant increase was observed in serum HDL\u2010C (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0\u02c2\u00a0.001) after intervention with the pomegranate extract. However, no significant difference was shown between the two groups in serum insulin and LDL\u2010C. The pomegranate extract supplement could be used as a complementary therapy along with existing therapies to improve glycemic indicators, serum lipids, anthropometric indices, and blood pressure in patients with nonalcoholic fatty liver.\n                  <\/jats:p>","DOI":"10.1002\/ptr.7249","type":"journal-article","created":{"date-parts":[[2021,9,8]],"date-time":"2021-09-08T22:14:47Z","timestamp":1631139287000},"page":"5871-5882","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["The effect of pomegranate extract on anthropometric indices, serum lipids, glycemic indicators, and blood pressure in patients with nonalcoholic fatty liver disease: A randomized double\u2010blind clinical trial"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7369-1381","authenticated-orcid":false,"given":"Reza","family":"Goodarzi","sequence":"first","affiliation":[{"name":"Nutrition and Metabolic Diseases Research Center Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"},{"name":"Department of Nutrition School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3161-5329","authenticated-orcid":false,"given":"Sima","family":"Jafarirad","sequence":"additional","affiliation":[{"name":"Nutrition and Metabolic Diseases Research Center Clinical Sciences Research Institute, Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"},{"name":"Department of Nutrition School of Allied Medical Sciences, Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4175-8099","authenticated-orcid":false,"given":"Narges","family":"Mohammadtaghvaei","sequence":"additional","affiliation":[{"name":"Hyperlipidemia Research Center Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5268-334X","authenticated-orcid":false,"given":"Maryam","family":"Dastoorpoor","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pejman","family":"Alavinejad","sequence":"additional","affiliation":[{"name":"Research Institute for Infectious Disease of Digestive System Ahvaz Jundishapur University of Medical Sciences  Ahvaz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,8]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00226.2001"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6820"},{"key":"e_1_2_11_4_1","unstructured":"Ahmadian M.(2012).The effect of pomegranate fruit husk extract on nonalcoholic fatty liver disease(Unpublished doctoral dissertation). 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