{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T11:24:30Z","timestamp":1769081070330,"version":"3.49.0"},"reference-count":32,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004160","name":"Mazandaran University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004160","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:p>For a long time, <jats:italic>Melissa officinalis<\/jats:italic> (<jats:italic>M<\/jats:italic>. <jats:italic>officinalis<\/jats:italic>) has been used to treat cardiovascular diseases. Therefore, this study aimed at evaluating the effects of <jats:italic>M. officinalis<\/jats:italic> on systolic and diastolic blood pressures in hypertensive patients. We conducted a double\u2010blind, controlled, randomized crossover clinical trial on 49 patients who received either <jats:italic>M. officinalis<\/jats:italic> capsules (400\u2009mg\/d; <jats:italic>n<\/jats:italic>\u00a0=\u200923) or the placebo (<jats:italic>n<\/jats:italic>\u00a0=\u200926) three times per day for a 4\u2010week period. After a 2\u2010week washout period, the <jats:italic>M. officinalis<\/jats:italic> group received placebo and the other group received <jats:italic>M. officinalis<\/jats:italic> for another 4\u2010week period. The systolic and diastolic blood pressures were measured once at baseline and then every 2\u2009weeks for 10\u2009weeks. The statistical analysis of the obtained data revealed that the chronology of the consumption of <jats:italic>M. officinalis<\/jats:italic> and placebo had no effect on the systolic and diastolic blood pressures in these two studied groups. Moreover, it was found that systolic and diastolic blood pressures significantly decreased after the consumption of <jats:italic>M. officinalis<\/jats:italic>, compared to placebo. Systolic and diastolic blood pressures in group A at the beginning of the study were 152.30\u2009\u00b1\u20095.312\u2009mmHg and 95.52\u2009\u00b1\u20091.988\u2009mmHg, respectively, and, after the first phase (drug use), reached 129.88\u2009\u00b1\u20099.009\u2009mmHg and 80.13\u2009\u00b1\u20095.488\u2009mmHg, respectively. Systolic and diastolic blood pressures in group B at the beginning of the study was 152.26\u2009\u00b1\u20095.640\u2009mmHg and 94.44\u2009\u00b1\u20092.607\u2009mmHg, respectively, and after the second phase (drug use), reached 131.77\u2009\u00b1\u20098.091\u2009mmHg and 81.46\u2009\u00b1\u20097.426\u2009mmHg, (<jats:italic>p<\/jats:italic>\u00a0=\u2009.005), respectively. Also, no significant side effects were observed during the study. According to the results, <jats:italic>M. officinalis<\/jats:italic> can reduce systolic and diastolic blood pressures of the patients with essential hypertension.<\/jats:p>","DOI":"10.1002\/ptr.7251","type":"journal-article","created":{"date-parts":[[2021,11,12]],"date-time":"2021-11-12T02:01:29Z","timestamp":1636682489000},"page":"6883-6892","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of <i>Melissa officinalis<\/i> on systolic and diastolic blood pressures in essential hypertension: A <scp>double\u2010blind<\/scp> crossover clinical trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Zahra","family":"Shekarriz","sequence":"first","affiliation":[{"name":"Faculty of Medicine Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Student Research Committee, Traditional and Complementary Medicine Research Center, Addiction Institute Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seyed Afshin","family":"Shorofi","sequence":"additional","affiliation":[{"name":"Department of Medical Surgical Nursing, School of Nursing and Midwifery Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Traditional and Complementary Medicine Research Center, Addiction Research Institutes Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maryam","family":"Nabati","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Faculty of Medicine Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bizhan","family":"Shabankhani","sequence":"additional","affiliation":[{"name":"Department of Biostatistics and Epidemiology, School of Health Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0204-0837","authenticated-orcid":false,"given":"Seyde Sedighe","family":"Yousefi","sequence":"additional","affiliation":[{"name":"Faculty of Medicine Mazandaran University of Medical Sciences  Sari Iran"},{"name":"Traditional and Complementary Medicine Research Center, Addiction Research Institutes Mazandaran University of Medical Sciences  Sari Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6254"},{"key":"e_1_2_10_3_1","volume-title":"Braunwald's Heart Disease: A Textbook of Cadiovascular Medicine, 2\u2010Volume Set","author":"Bonow R. 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