{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:23:18Z","timestamp":1790810598378,"version":"4.1.0"},"reference-count":44,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:00:00Z","timestamp":1632096000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004320","name":"Shiraz University of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004320","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Systemic arterial hypertension is an independent risk factor for coronary heart disease, stroke, heart failure, and chronic kidney diseases. Spirulina is microalgae with nutritious ingredients and has potential attenuating effects on chronic diseases including hypertension. Spirulina can be added to food products in order to develop functional foods. The aim of this study was to assess the effects of 8\u2010week consumption of a salad dressing containing 2\u2009g of spirulina platensis powder versus a placebo dressing on patients with hypertension. In this triple\u2010blind randomized clinical trial, 48 patients with hypertension were enrolled to receive daily either spirulina\u2010fortified dressing or placebo for 2\u2009months. A total of 41 patients completed this study. We observed that the consumption of spirulina dressing significantly reduced systolic blood pressure (<jats:italic>p<\/jats:italic>\u00a0=\u2009.02), diastolic blood pressure (<jats:italic>p<\/jats:italic>\u00a0=\u2009.03), serum triglyceride (<jats:italic>p<\/jats:italic>\u00a0=\u2009.01), total cholesterol, and low\u2010density lipoprotein (LDL) levels, compared to nonsignificant changes in the placebo group. Significant changes in TAC and hs\u2010CRP levels were observed in none of the groups. According to our findings, spirulina\u2010fortified dressing as a functional food can be used a supportive treatment for patients with hypertension along with standard antihypertensive drugs. However, further investigations are required for a more comprehensive conclusion.<\/jats:p>","DOI":"10.1002\/ptr.7254","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T12:21:13Z","timestamp":1632140473000},"page":"6181-6190","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":39,"title":["Antihypertensive and antihyperlipemic of spirulina (Arthrospira platensis) sauce on patients with hypertension: A randomized triple\u2010blind placebo\u2010controlled clinical trial"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4267-0240","authenticated-orcid":false,"given":"Zohreh","family":"Ghaem Far","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition, School of Nutrition and Food Sciences Shiraz University of Medical Sciences  Shiraz 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