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Systematic reviews (SRs) of randomized trials were identified through a comprehensive search in several databases, and their methodological quality were evaluated with AMSTAR\u20102. The results for main outcomes are presented, prioritizing those from updated and better quality SRs. Finally, 68 SRs, addressing 37 different health conditions, were included. The methodological quality was high for eight SRs. The evidence certainty (GRADE) for the effects of cannabinoids is not high for any of the outcomes identified. Evidence certainty was moderate for the following: (a) cannabidiol appears to be beneficial for quality of life but increases the risk of adverse events in ulcerative colitis; (b) cannabinoids in general appear to have no clinically important benefit for chronic non\u2010oncologic pain, spasticity\u2010related pain in multiple sclerosis, or for acute post\u2010operative pain; (c) cannabinoids in general appear to have a benefit in reducing chemotherapy\u2010related nausea and vomiting. For all other outcomes from remaining comparisons, the evidence certainty was low, very low, or not evaluated, which prevents recommendations for or against their routine use.<\/jats:p>","DOI":"10.1002\/ptr.7263","type":"journal-article","created":{"date-parts":[[2021,11,29]],"date-time":"2021-11-29T09:59:15Z","timestamp":1638179955000},"page":"5-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Efficacy and safety of therapeutic use of cannabis derivatives and their synthetic analogs: Overview of systematic reviews"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9522-1871","authenticated-orcid":false,"given":"Rachel","family":"Riera","sequence":"first","affiliation":[{"name":"Health Technology Assessment Centre Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo \u2010 SP Brazil"},{"name":"Escola Paulista de Medicina (EPM) Universidade Federal de S\u00e3o Paulo (Unifesp)  S\u00e3o Paulo \u2010 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7487-8471","authenticated-orcid":false,"given":"Rafael Leite","family":"Pacheco","sequence":"additional","affiliation":[{"name":"Health Technology Assessment Centre Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo \u2010 SP Brazil"},{"name":"Escola Paulista de Medicina (EPM) Universidade Federal de S\u00e3o Paulo (Unifesp)  S\u00e3o Paulo \u2010 SP Brazil"},{"name":"Centro de Pesquisa M\u00e9dica Centro Universit\u00e1rio S\u00e3o Camilo (CUSC)  S\u00e3o Paulo \u2010 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4281-2536","authenticated-orcid":false,"given":"\u00c2ngela Maria","family":"Bagattini","sequence":"additional","affiliation":[{"name":"Health Technology Assessment Centre Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo \u2010 SP Brazil"},{"name":"Instituto de Medicina Tropical e Sa\u00fade Publica Universidade Federal de Goi\u00e1s (UFG)  Goi\u00e2nia \u2010 GO Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4361-4526","authenticated-orcid":false,"given":"Ana Luiza Cabrera","family":"Martimbianco","sequence":"additional","affiliation":[{"name":"Health Technology Assessment Centre Hospital S\u00edrio\u2010Liban\u00eas  S\u00e3o Paulo \u2010 SP Brazil"},{"name":"Mestrado Profissional em Sa\u00fade e Meio Ambiente Universidade Metropolitana de Santos (Unimes)  Santos \u2010 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejim.2018.01.003"},{"issue":"3","key":"e_1_2_10_3_1","first-page":"e19","article-title":"The efficacy of pharmaceutical cannabinoids in the management of cannabis use disorder: A systematic review","volume":"26","author":"Alkabbani W.","year":"2019","journal-title":"Journal of Population Therapeutics and Clinical Pharmacology"},{"key":"e_1_2_10_4_1","unstructured":"Amato L. 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