{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:46:38Z","timestamp":1788353198040,"version":"build-2803163510"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,28]],"date-time":"2021-09-28T00:00:00Z","timestamp":1632787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006206","name":"\u010cesk\u00e1 Zem\u011bd\u011blsk\u00e1 Univerzita v Praze","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006206","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007397","name":"Univerzita Karlova v Praze","doi-asserted-by":"publisher","award":["IGA No 20205004"],"award-info":[{"award-number":["IGA No 20205004"]}],"id":[{"id":"10.13039\/100007397","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>Male infertility refers to the inability to conceive a natural pregnancy in a fertile female, and approximately 15% of reproductive\u2010aged couples worldwide face this problem. Several plants were used to treat fertility disorders and, among them, <jats:italic>Lepidium meyenii<\/jats:italic>, a folk medicament of Andean regions, is still used to enhance vitality and treat sterility in humans and domestic animals. The aim of the study was to evaluate the effects of <jats:italic>L. meyenii<\/jats:italic> Walpers on infertile patients by a randomized, double\u2010blind, placebo\u2010controlled trial. Fifty patients suffering from various reproductive\u2010related problems were enrolled for 16\u2009weeks to evaluate the effect of yellow maca on semen quality and serum hormone levels. Treatment with maca improved the percentage of sperm concentration by 40%, whereas the placebo improved by 76% after 8 and 16\u2009weeks of treatment, but the results were statistically non\u2010significant. No statistically significant change in hormone levels was reported by using maca, except a decrease in the level of free testosterone. Results are not sufficient to assess the efficacy of maca on male fertility. Further investigation and trials are required to obtain conclusive results.<\/jats:p>","DOI":"10.1002\/ptr.7287","type":"journal-article","created":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T02:40:08Z","timestamp":1632883208000},"page":"6359-6368","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Evaluation of the effect of <i>Lepidium meyenii<\/i> Walpers in infertile patients: A randomized, double\u2010blind, placebo\u2010controlled trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Ingrid","family":"Melnikovova","sequence":"first","affiliation":[{"name":"Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences Czech University of Life Sciences Prague  Prague 6 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Russo","sequence":"additional","affiliation":[{"name":"Department of Science University of Basilicata  Potenza Italy"},{"name":"Spinoff BioActiPlants.r.l., Department of Science University of Basilicata  Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2812-9274","authenticated-orcid":false,"given":"Tomas","family":"Fait","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Second Faculty of Medicine Charles University  Prague 5 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michaela","family":"Kolarova","sequence":"additional","affiliation":[{"name":"Department of Agroecology and Biometeorology, Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague  Prague 6 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Tauchen","sequence":"additional","affiliation":[{"name":"Department of Food Science, Faculty of Agrobiology, Food and Natural Resources Czech University of Life Sciences Prague  Praha Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nataliya","family":"Kushniruk","sequence":"additional","affiliation":[{"name":"First Medical Faculty of Charles University Prague  Prague 2 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Falabella","sequence":"additional","affiliation":[{"name":"Urology Unit San Carlo Hospital, Via Potito Petrone  Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5874-1237","authenticated-orcid":false,"given":"Luigi","family":"Milella","sequence":"additional","affiliation":[{"name":"Department of Science University of Basilicata  Potenza Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloy","family":"Fern\u00e1ndez Cusimamani","sequence":"additional","affiliation":[{"name":"Department of Crop Sciences and Agroforestry, Faculty of Tropical AgriSciences Czech University of Life Sciences Prague  Prague 6 Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,9,28]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13509"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.13755"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5998"},{"key":"e_1_2_10_5_1","volume-title":"Utilizacion de diferentes niveles de Maca en la fertilidad de cobayos","author":"Alvarez C. 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