{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,28]],"date-time":"2025-11-28T12:31:17Z","timestamp":1764333077489,"version":"3.40.5"},"reference-count":39,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T00:00:00Z","timestamp":1631836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>This double\u2010blind study was designed to evaluate the efficacy of a syrup made from <jats:italic>Myrtus communis<\/jats:italic> L. fruit on children with gastroesophageal reflux disease. Children aged 1\u20137\u2009years old, diagnosed with gastroesophageal reflux disease (GERD), were randomly allocated to either intervention group (omeprazole and \u201cmyrtle fruit syrup\u201d) or control group (omeprazole and placebo syrup). GERD symptom questionnaire for young children (GSQ\u2010YC) was filled out for each patient at zeroth and eighth week, and also 4\u2009weeks after cessation of intervention. No statistically significant difference between two groups in terms of GERD score was reported neither in 8th nor in 12th week assessments. During the 4\u2009weeks of the drug\u2010free period, patients in myrtle group did not experience a large shift in GERD score, while patients in placebo syrup group experienced an increase of as much as 19.4. However, this difference was not statistically significant, although it could be significant clinically. For achieving more conclusive results, more studies are needed. The symptom \u201crefusal to eat\u201d in the intervention group was less than in placebo group after 8\u2009weeks (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.018) and at the end of the study (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.042). So myrtle fruit syrup may be considered for children with low appetite.<\/jats:p>","DOI":"10.1002\/ptr.7288","type":"journal-article","created":{"date-parts":[[2021,9,17]],"date-time":"2021-09-17T10:06:00Z","timestamp":1631873160000},"page":"6369-6376","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Myrtle (<i>Myrtus communis<\/i> L.) fruit syrup for gastroesophageal reflux disease in children: A double\u2010blind randomized clinical trial"],"prefix":"10.1002","volume":"35","author":[{"given":"Maryam Sadat","family":"Paknejad","sequence":"first","affiliation":[{"name":"School of Traditional Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kambiz","family":"Eftekhari","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology and Hepatology Research Center, Department of Pediatrics Bahrami Children's Hospital, Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8637-4350","authenticated-orcid":false,"given":"Roja","family":"Rahimi","sequence":"additional","affiliation":[{"name":"School of Traditional Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohsen","family":"Vigeh","sequence":"additional","affiliation":[{"name":"Maternal, Fetal, and Neonatal Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Epidemiology and Environmental Health Juntendo University  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayeh","family":"Naghizadeh","sequence":"additional","affiliation":[{"name":"School of Traditional Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5395-819X","authenticated-orcid":false,"given":"Mehrdad","family":"Karimi","sequence":"additional","affiliation":[{"name":"School of Traditional Medicine Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5122"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-009-0267-3"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/MEG.0000000000000979"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.12619"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/09735070.2013.11886456"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2004.30098.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2012-304269"},{"issue":"5","key":"e_1_2_8_9_1","first-page":"354","article-title":"Deprescribing proton pump inhibitors: Evidence\u2010based clinical practice guideline","volume":"63","author":"Farrell B.","year":"2017","journal-title":"Canadian Family Physician"},{"issue":"1","key":"e_1_2_8_10_1","first-page":"35","article-title":"Reporting randomised, controlled trials of herbal interventions: An elaborated CONSORT statement","volume":"1","author":"Gagnier J. 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