{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T23:46:25Z","timestamp":1793490385412,"version":"4.5.0"},"reference-count":42,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2021,9,19]],"date-time":"2021-09-19T00:00:00Z","timestamp":1632009600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011917","name":"Hormozgan University of Medical Sciences","doi-asserted-by":"publisher","award":["990126"],"award-info":[{"award-number":["990126"]}],"id":[{"id":"10.13039\/501100011917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:p>In COVID\u201019 patients, cytokine storm due to excessive immune responses can cause severe complications. In this study, we investigated the effect of curcumin nanomicelles on clinical outcome and cellular immune responses subtypes changes in COVID\u201019 patients. A randomized, triple\u2010blinded, placebo\u2010controlled study was done. Forty COVID\u201019 patients were included into two groups of nano\u2010curcumin and placebo. The nano\u2010curcumin group received 40\u2009mg of nano\u2010curcumin capsule, four times per day for 2\u2009weeks. Clinical signs and gene expression of TBX21, GATA3, RORC and FOXP3 genes and IFN\u2010\u03b3, IL\u20104, IL\u201017 and TGF\u2010\u03b2 cytokines serum levels were measured at time points of 0, 7 and 14\u2009days. Serum levels of IFN\u2010\u03b3 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.52) and IL\u201017 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.11) decreased, while IL\u20104 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.12) and TGF\u2010\u03b2 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.14) increased in the nano\u2010curcumin group compared with placebo on day 14. Moreover, gene expressions of TBX21 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.02) and FOXP3 (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.005) genes were significantly decreased and increased between nano\u2010curcumin and placebo groups on day 7, respectively. It can be concluded that administration of nano\u2010curcumin in inflammatory phase of COVID\u201019 can accelerate recovering of the acute inflammatory phase by modulating inflammatory immune responses. Therefore, it is suggested that this supplement in inflammatory diseases, including COVID\u201019, can be effective in controlling the inflammatory responses.<\/jats:p>","DOI":"10.1002\/ptr.7294","type":"journal-article","created":{"date-parts":[[2021,9,20]],"date-time":"2021-09-20T00:39:36Z","timestamp":1632098376000},"page":"6417-6427","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":71,"title":["A triple\u2010blind, placebo\u2010controlled, randomized clinical trial to evaluate the effect of curcumin\u2010containing nanomicelles on cellular immune responses subtypes and clinical outcome in<scp>COVID<\/scp>\u201019 patients"],"prefix":"10.1002","volume":"35","author":[{"given":"Mehdi","family":"Hassaniazad","sequence":"first","affiliation":[{"name":"Infectious and Tropical Diseases Research Center, Hormozgan Health Institute Hormozgan University of Medical Sciences Bandar Abbas 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