{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:59:45Z","timestamp":1772254785239,"version":"3.50.1"},"reference-count":29,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T00:00:00Z","timestamp":1636934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["18fk0410008h003"],"award-info":[{"award-number":["18fk0410008h003"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["16K08742"],"award-info":[{"award-number":["16K08742"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2021,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Acanthoic acid (AA) is an active substance that is extracted from <jats:italic>Croton oblongifolius<\/jats:italic> Roxb., a traditional plant in Thailand. The antiinflammatory effect of AA on NF\u2010\u03baB pathway has been exclusively reported, however, its anticancer effect is still lacking. PEL is a B cell lymphoma that is mostly found in HIV patients. The prognosis and progression of PEL patients are terribly poor with a median survival time less than 6\u00a0months, so the new effective treatment is urgently needed. In this study, we found that AA effectively inhibited PEL cell proliferation with IC50s at 120\u2013130\u2009\u03bcM in well\u2010representative cells, while the IC50s of AA in PBMC were higher (&gt;200\u2009\u03bcM). AA increased percentages of Annexin V\/PI positive cells, whereas adding of caspase inhibitor (Q\u2010VD\u2010OPh) prevented AA\u2010induced cell death. The antiapoptotic protein, c\u2010FLIP, was downregulated by AA which leading to the activation of caspase\u20108 and \u20103. Combination of AA and TRAIL dramatically enhanced apoptotic cell death. In PEL xenograft model, AA at the dose of 250\u2009mg\/kg effectively inhibited PEL tumor growth without detectable toxicities assessed by mice weight and appearance.<\/jats:p>","DOI":"10.1002\/ptr.7322","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T08:37:56Z","timestamp":1636965476000},"page":"7018-7026","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antitumor effect of acanthoic acid against primary effusion lymphoma via inhibition of <scp>c\u2010FLIP<\/scp>"],"prefix":"10.1002","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5855-5285","authenticated-orcid":false,"given":"Gunya","family":"Sittithumcharee","sequence":"first","affiliation":[{"name":"Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection Kumamoto University  Kumamoto Japan"},{"name":"Division of Hematopoiesis Graduate School of Medical Sciences, Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryusho","family":"Kariya","sequence":"additional","affiliation":[{"name":"Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teerapich","family":"Kasemsuk","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science and Technology Rambhai Barni Rajabhat University  Chanthaburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rungnapha","family":"Saeeng","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Faculty of Science Burapha University  Chonburi Thailand"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3124-5206","authenticated-orcid":false,"given":"Seiji","family":"Okada","sequence":"additional","affiliation":[{"name":"Division of Hematopoiesis, Joint Research Center for Human Retrovirus Infection Kumamoto University  Kumamoto Japan"},{"name":"Division of Hematopoiesis Graduate School of Medical Sciences, Kumamoto University  Kumamoto Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,15]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.281.5381.1305"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.12-5-569"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00691"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-08-2525"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.221"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2012.02212.x"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12185-013-1339-3"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2010.12.034"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2007.00617.x"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1006\/cimm.1996.0154"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9071(199908)58:4<394::AID-JMV12>3.0.CO;2-H"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.148585"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cccn.2004.01.004"},{"issue":"2","key":"e_1_2_11_15_1","first-page":"335","article-title":"Molecular determinants of response to TRAIL in killing of Normal and cancer cells","volume":"6","author":"Kim K.","year":"2000","journal-title":"Clinical Cancer Research"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2012.05.067"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/np50060a005"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M101780200"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.3109\/13880209.2011.559476"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2014.81"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110480200"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05506-9"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.31.738"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.5582\/irdr.2014.01010"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30112"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/539748"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-008-8103-5"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1107\/S1600536810019483"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1204895"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2009.07.011"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7322","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.7322","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7322","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T23:31:18Z","timestamp":1692833478000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.7322"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,15]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,12]]}},"alternative-id":["10.1002\/ptr.7322"],"URL":"https:\/\/doi.org\/10.1002\/ptr.7322","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,15]]},"assertion":[{"value":"2021-04-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}