{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T15:13:22Z","timestamp":1791645202152,"version":"4.3.4"},"reference-count":83,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Functional dyspepsia (FD) is a very common condition globally. Relevant keywords were searched for in title and abstract of selected databases, that is, Medline\/PubMed, Scopus, Embase, Web of knowledge, and Google Scholar. Placebo and active\u2010control trials on herbal remedies amongst adults who were diagnosed with FD were included. Dichotomous outcomes were presented as relative risk (RR) with 95% confidence interval (CI) and continuous outcomes were presented as pooled standardized mean difference (SMD) with 95% CI. Forty\u2010nine randomized controlled trials (RCTs) were entered into meta\u2010analysis (6,987 subjects). Herbal remedies resulted in a higher improvement in FD symptoms in comparison with the placebo (SMD\u00a0= \u22120.58 [\u22120.66\u2013 \u22120.51],<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.00001 and RR\u00a0=\u00a01.73 [1.62\u20131.85],<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.00001). No significant difference between herbal remedies and placebo in the incidence of adverse events was observed (12.27 vs. 8.41%, RR\u00a0=\u00a01.06 [0.91\u20131.23],<jats:italic>p<\/jats:italic>\u00a0=\u00a0.45). Also, herbal remedies resulted in a higher improvement in quality of life in comparison with placebo (SMD\u00a0=\u00a0\u22120.64 [\u22120.73\u2013 \u22120.55],<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.00001). When comparing herbal remedies with conventional medicine through sensitivity analysis, no outcomes were significantly different (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). Herbal remedies might be efficacious and safe in treating FD, and demonstrate comparable effect sizes for efficacy to conventional treatments. Further high\u2010quality studies are warranted to firmly establish the clinical efficacy of the herbal remedies.<\/jats:p>","DOI":"10.1002\/ptr.7333","type":"journal-article","created":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T14:59:03Z","timestamp":1638370743000},"page":"686-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy of herbal treatments for functional dyspepsia: A systematic review and meta\u2010analysis of randomized clinical trials"],"prefix":"10.1002","volume":"36","author":[{"given":"Alireza","family":"Heiran","sequence":"first","affiliation":[{"name":"Non\u2010communicable Diseases Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamran","family":"Bagheri Lankarani","sequence":"additional","affiliation":[{"name":"Health Policy Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Bradley","sequence":"additional","affiliation":[{"name":"Helfgott Research Institute National University of Natural Medicine Portland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Simab","sequence":"additional","affiliation":[{"name":"Student Research Committee, School of Medicine Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2458-2626","authenticated-orcid":false,"given":"Mehdi","family":"Pasalar","sequence":"additional","affiliation":[{"name":"Research Center for Traditional Medicine and History of Medicine Shiraz University of Medical Sciences Shiraz 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