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Here we investigated the cytotoxic and immunomodulatory effects of the ethanol solution extract of propolis (EEP) in combination with DTX on MCF\u20107 breast cancer cells and on women's monocyte. The cytotoxic potential of EEP\u2009+\u2009DTX was assessed by MTT assay and the type of tumor cell death was evaluated by flow cytometry. The effects of EEP\u2009+\u2009DTX on the migration and invasion of MCF\u20107 cells were analyzed. Cytokine production by monocytes was assessed by ELISA and the expression of cell surface markers was evaluated by flow cytometry. We also assessed the fungicidal activity of monocytes against <jats:italic>Candida albicans<\/jats:italic> and the generation of reactive oxygen species (ROS). Finally, the impact of the supernatants of treated monocytes in the viability, migration, and invasiveness of tumor cells was assessed. EEP enhanced the cytotoxicity of DTX alone against MCF\u20107 cells by inducing necrosis and inhibiting their migratory ability. EEP\u2009+\u2009DTX exerted no cytotoxic effects on monocytes and stimulated HLA\u2010DR expression, TNF\u2010\u03b1, and IL\u20106 production, exerted an immunorestorative action in the fungicidal activity, and reduced the oxidative stress. Our findings have practical implications and reveal new insights for complementary medicine.<\/jats:p>","DOI":"10.1002\/ptr.7345","type":"journal-article","created":{"date-parts":[[2021,12,4]],"date-time":"2021-12-04T12:06:32Z","timestamp":1638619592000},"page":"448-461","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Brazilian green propolis: A novel tool to improve the cytotoxic and immunomodulatory action of docetaxel on <scp>MCF<\/scp>\u20107 breast cancer cells and on women monocyte"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4722-3733","authenticated-orcid":false,"given":"Eliza","family":"de Oliveira Cardoso","sequence":"first","affiliation":[{"name":"Department of Chemical and Biological Sciences Institute of Biosciences, S\u00e3o Paulo State University (UNESP), Campus Botucatu  S\u00e3o Paulo 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