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Therefore, the clinical efficacy of this substance has been largely investigated for curing numerous disorders. Based on a growing body of literature, this review aimed to investigate curcumin's molecular and clinical effects on reproduction and related disorders. Curcumin in the female reproductive system attenuates folliculogenesis, promotes apoptosis of oocytes and blastocyst, and decreases embryo implantation and survival. Curcumin at &lt;100\u2009mg concentration shows protective effects against testicular injury. The concentration of &gt;250\u2009mg of curcumin exhibits immobilizing action on sperms, and at 500\u2009mg concentration completely blocks pregnancy. Curcumin inhibits vaginal infections, attenuates the severity of the premenstrual syndrome, ameliorates inflammatory conditions in polycystic ovary syndrome, improves preeclampsia, and prevents ectopic endometrial lesions. Taken together, curcumin, because of the numerous biological activities, low level of toxicity, and lower adverse effects compared to the synthetic drugs, could be considered as a protective agent for preserving the semen quality parameters, a contraceptive, and chemotherapeutic or chemopreventive agent, as well as an appropriate agent for the treatment of female reproductive disorders.<\/jats:p>","DOI":"10.1002\/ptr.7360","type":"journal-article","created":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T08:49:45Z","timestamp":1642495785000},"page":"808-823","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["An overview of the therapeutic effects of curcumin in reproductive disorders with a focus on the antiinflammatory and immunomodulatory activities"],"prefix":"10.1002","volume":"36","author":[{"given":"Bita","family":"Saifi","sequence":"first","affiliation":[{"name":"Department of Anatomy, Mashhad Medical 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