{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T18:57:27Z","timestamp":1791572247792,"version":"4.3.4"},"reference-count":196,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Quercitrin is a naturally available type of flavonoid that commonly functions as the dietary ingredient and supplement. So far, a wide spectrum of bioactivities of quercitrin have been revealed, including antioxidative stress, antiinflammation, anti\u2010microorganisms, immunomodulation, analgesia, wound healing, and vasodilation. Based on these various pharmacological activities, increasing studies have focused on the potency of quercitrin in diverse diseases in recent years, such as bone metabolic diseases, gastrointestinal diseases, cardiovascular and cerebrovascular diseases, and others. In this paper, by collecting and summarizing publications from the recent years, the natural sources, pharmacological activities and roles in various diseases, pharmacokinetics, structure\u2013activity relationship, as well as the toxicity of quercitrin were systematically reviewed. In addition, the underlying molecular mechanisms of quercitrin in treating related diseases, the dose\u2010effect relationships, and the novel preparations were discussed on the purpose of broadening the application prospect of quercitrin as functional food and providing reference for its clinical application. Notably, clinical studies of quercitrin are insufficient at present, further high\u2010quality studies are needed to firmly establish the clinical efficacy of quercitrin.<\/jats:p>","DOI":"10.1002\/ptr.7397","type":"journal-article","created":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T10:03:46Z","timestamp":1646647426000},"page":"1545-1575","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":136,"title":["Chemistry, pharmacokinetics, pharmacological activities, and toxicity of Quercitrin"],"prefix":"10.1002","volume":"36","author":[{"given":"Junren","family":"Chen","sequence":"first","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gangmin","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Sun","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0289-4426","authenticated-orcid":false,"given":"Fu","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"Department of Pharmacology, Key Laboratory of Drug\u2010Targeting and Drug Delivery System of the Education Ministry, Sichuan Engineering Laboratory for Plant\u2010Sourced Drug and Sichuan Research Center for Drug Precision Industrial Technology West China School of Pharmacy, Sichuan University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhu","family":"Tan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyu","family":"Cao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunli","family":"Tang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"},{"name":"Department of Pharmacology Guangxi University of Traditional Chinese Medicine  Guangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofang","family":"Xie","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8916-2302","authenticated-orcid":false,"given":"Cheng","family":"Peng","sequence":"additional","affiliation":[{"name":"Key Laboratory of Southwestern Chinese Medicine Resources Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,7]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.0000154789.28695.ea"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJPP11.371"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aao6459"},{"issue":"3","key":"e_1_2_15_5_1","first-page":"119","article-title":"Comparative toxicities of quercetin and quercitrin","volume":"41","author":"Ambrose A. M.","year":"1952","journal-title":"Journal of Pharmaceutical Sciences"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12016-018-8686-z"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2006.09.023"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-011-0927-x"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1472-8206.2009.00771.x"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-017-0313-8"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i45.17020"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)61909-7"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.3030400809"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.03.008"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01658"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2000-11119"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2005.12.009"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0705941"},{"issue":"11","key":"e_1_2_15_19_1","first-page":"1976","article-title":"Quercitrin promotes apoptosis of gastric cancer cell line SGC7901 by in\u2010 hibiting PI3K\/AKT signaling pathway","volume":"34","author":"Chen L. Y.","year":"2018","journal-title":"Chinese Journal of Pathophysiology"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2017.08.034"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2011.09.005"},{"issue":"19","key":"e_1_2_15_22_1","first-page":"7","article-title":"Immunomodulatory effects of quercetin on immunocompromised mice","volume":"35","author":"Chen Y. L.","year":"2019","journal-title":"Chinese Journal of Immunology"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjtm.2015.12.002"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etp.2010.08.008"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf9032443"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10068-012-0075-4"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2014.08.002"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12253-014-9825-3"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352-3018(17)30027-9"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20102407"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2017.2"},{"key":"e_1_2_15_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200425778"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19113319"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b05044"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2986796"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-016-9600-1"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2008.07.006"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.8b03154"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.3892\/ijmm.2012.1177"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-015-1208-0"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.19"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1300225"},{"issue":"1","key":"e_1_2_15_43_1","first-page":"59","article-title":"Inhibition of AP\u20101 and MAPK signaling and activation of Nrf2\/ARE pathway by quercitrin","volume":"36","author":"Ding M.","year":"2010","journal-title":"International Journal of Oncology"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2017.12.002"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30237-5"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf034543e"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.09.068"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2007.11.040"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/913152"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1211\/jpp.57.10.0014"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-959694"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2018.02.002"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0891-5849(98)00020-3"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00375-4"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60802-3"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2014.130438"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16593"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22444"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61128-3"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101036"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2018.05.008"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2020.06.020"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2011.12.001"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0944-7113(96)80075-4"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcm.2018.05.010"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0091736"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01014.x"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/62.6.1276"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1271\/bbb.120562"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1160\/TH07-03-0181"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22030353"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24213873"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-9861(52)90022-2"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14010027"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5591"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15054"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2013.09.019"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2018.05.004"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786410903339044"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/4307161"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.19845\/j.cnki.zfysjjbzz.2015.08.004"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-013-0172-9"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.25.022106.141623"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-020-00413-y"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0378-8741(99)00202-0"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2010.196"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2020.111817"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.22.749"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8080464"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25174004"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.4103\/0973-1296.149704"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2010.08.046"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2016.11.013"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2019.4610"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a001651"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-015-0585-8"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.13-RAI-0564"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/6530364"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.01023"},{"key":"e_1_2_15_100_1","doi-asserted-by":"publisher","DOI":"10.29219\/fnr.v64.3745"},{"issue":"03","key":"e_1_2_15_101_1","first-page":"192","article-title":"Roles of glucose transporter 1 and 2 in trans\u2010membrane absorption of quercetin and isoquercetin","volume":"32","author":"Li S. Y.","year":"2018","journal-title":"Chinese Journal of Pharmacology and Toxicology"},{"issue":"05","key":"e_1_2_15_102_1","first-page":"385","article-title":"Absorption and metabolism of quercetin in human colon carcinoma cell line cells","volume":"26","author":"Li S. Y.","year":"2010","journal-title":"Pharmaceutical Journal of Chinese People's Liberation Army"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00249.2015"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.19526\/j.cnki.1005-8915.20200403"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules21091246"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-018-0976-0"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2006-957690"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules20046533"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.13699\/j.cnki.1001-6821.2020.15.035"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00356"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(02)00064-8"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1005-9903.2010.09.048"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.35414"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9030855"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-032713-120225"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.7539\/j.issn.1672-2981.2021.01.008"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1039\/c5fo00913h"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2015.56"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1080\/10715760000301181"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.309008"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2020.127983"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-873183"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703054"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12082276"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1161\/atvbaha.117.309228"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/s8756-3282(00)00368-9"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153363"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1177\/1934578X1601101107"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.4161\/oxim.2.5.9498"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)04904-7"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415x21500233"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00251"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00378"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.03.042"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.19540\/j.cnki.cjcmm.20161222.018"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.43.1800"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0175-6"},{"key":"e_1_2_15_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrrheum.2016.136"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/0031-9422(95)00507-4"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2009.55"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00067.2017"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1039\/c7fo00755h"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2015.1982"},{"key":"e_1_2_15_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16305-8"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0024-3205(02)01568-0"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-013-0044-3"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.09.009"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.5593"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-079x.2002.1819.x"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27607"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-020-0230-3"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.16705\/j.cnki.1004-1850.2020.01.002"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/7875396"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2020.153387"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.1c00371"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1534-5807(02)00369-6"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/7039802"},{"key":"e_1_2_15_159_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1008-049X.2016.08.007"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172246"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2015-1669"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/4535194"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncb1821"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu8070431"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2016.53"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf900998q"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2004.12.018"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fct.2014.03.018"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0035-1546034"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2006.05.084"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coph.2005.06.004"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415x21500270"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.13764\/j.cnki.ncdm.2020.06.002"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.13345\/j.cjb.200769"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2015.12.047"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.01.001"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.02.073"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.16720\/j.cnki.tcyj.2014.02.013"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.586010"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.talanta.2005.05.027"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.19288\/j.cnki.issn.1000-2723.2018.04.001"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.13493\/j.issn.1672-7878.2020.09-004"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2016.10.021"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotobiol.2012.05.020"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.3969\/j.issn.1008-0805.2013.01.038"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.117.014530"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.03.015"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1471-4914(02)00009-6"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02978831"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-015-0638-z"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.14188\/j.1671-8852.2017.1198"},{"key":"e_1_2_15_192_1","doi-asserted-by":"publisher","DOI":"10.3977\/j.issn.1005-8478.2015.23.16"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.13982\/j.mfst.1673-9078.2013.03.003"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molp.2017.08.013"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1080\/00498254.2019.1700319"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-016-9504-y"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-030409-101212"}],"container-title":["Phytotherapy Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7397","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/ptr.7397","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/ptr.7397","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T10:33:32Z","timestamp":1692959612000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/ptr.7397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3,7]]},"references-count":196,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/ptr.7397"],"URL":"https:\/\/doi.org\/10.1002\/ptr.7397","archive":["Portico"],"relation":{},"ISSN":["0951-418X","1099-1573"],"issn-type":[{"value":"0951-418X","type":"print"},{"value":"1099-1573","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,3,7]]},"assertion":[{"value":"2021-09-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-03-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}