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Alpha\u2010lipoic acid (\u03b1\u2010LA) possesses various pharmacological effects, including antidiabetic, antiobesity, hypotensive, and hypolipidemia actions. It exhibits reactive oxygen species scavenger properties against oxidation and age\u2010related inflammation and refines MetS components. Also, \u03b1\u2010LA activates the 5\u2032 adenosine monophosphate\u2010activated protein kinase and inhibits the NF\u03bab. It can decrease cholesterol biosynthesis, fatty acid \u03b2\u2010oxidation, and vascular stiffness. \u03b1\u2010LA decreases lipogenesis, cholesterol biosynthesis, low\u2010density lipoprotein and very low\u2010density lipoprotein levels, and atherosclerosis. Moreover, \u03b1\u2010LA increases insulin secretion, glucose transport, and insulin sensitivity. These changes occur via PI3K\/Akt activation. On the other hand, \u03b1\u2010LA treats central obesity by increasing adiponectin levels and mitochondrial biogenesis and can reduce food intake mainly by SIRT1 stimulation. In this review, the most relevant articles have been discussed to determine the effects of \u03b1\u2010LA on different components of MetS with a special focus on different molecular mechanisms behind these effects. This review exhibits the potential properties of \u03b1\u2010LA in managing MetS; however, high\u2010quality studies are needed to confirm the clinical efficacy of \u03b1\u2010LA.<\/jats:p>","DOI":"10.1002\/ptr.7406","type":"journal-article","created":{"date-parts":[[2022,3,2]],"date-time":"2022-03-02T07:09:37Z","timestamp":1646204977000},"page":"2300-2323","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Effects of alpha lipoic acid on metabolic syndrome: A comprehensive review"],"prefix":"10.1002","volume":"36","author":[{"given":"Nahid","family":"Najafi","sequence":"first","affiliation":[{"name":"Student Research Committee Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Department of Pharmacodynamics and Toxicology, School Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9697-2343","authenticated-orcid":false,"given":"Soghra","family":"Mehri","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, School Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5491-572X","authenticated-orcid":false,"given":"Mahboobeh","family":"Ghasemzadeh Rahbardar","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, School Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-851X","authenticated-orcid":false,"given":"Hossein","family":"Hosseinzadeh","sequence":"additional","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology, School Pharmacy Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Pharmaceutical Research Center, Pharmaceutical Technology Institute Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,2]]},"reference":[{"key":"e_1_2_23_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/01913123.2017.1286422"},{"key":"e_1_2_23_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12986-018-0274-y"},{"key":"e_1_2_23_4_1","doi-asserted-by":"publisher","DOI":"10.5812\/ircmj.65925"},{"key":"e_1_2_23_5_1","doi-asserted-by":"publisher","DOI":"10.3164\/jcbn.2008051"},{"key":"e_1_2_23_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-006-9408-z"},{"issue":"3","key":"e_1_2_23_7_1","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.37506\/ijphrd.v11i3.1580","article-title":"Evaluation of serum lipid profile after different chemotherapeutic regimens in Iraqi patients with breast cancer","volume":"11","author":"Anber H.","year":"2020","journal-title":"Indian Journal of Public Health Research and Development"},{"issue":"6","key":"e_1_2_23_8_1","first-page":"584","article-title":"Effect of alpha\u2010lipoic acid on blood glucose, insulin resistance, and glutathione peroxidase of type 2 diabetic patients","volume":"32","author":"Ansar H.","year":"2011","journal-title":"Saudi Medical Journal"},{"key":"e_1_2_23_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2018.1519795"},{"key":"e_1_2_23_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.13842"},{"key":"e_1_2_23_11_1","doi-asserted-by":"publisher","DOI":"10.4183\/aeb.2017.461"},{"key":"e_1_2_23_12_1","doi-asserted-by":"publisher","DOI":"10.3803\/EnM.2013.28.4.326"},{"key":"e_1_2_23_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20010126"},{"issue":"2","key":"e_1_2_23_14_1","first-page":"124","article-title":"Investigation on the role of alpha lipoic acid in glipizide treatment in diabetic rats","volume":"2","author":"Banji D.","year":"2011","journal-title":"International Journal of Pharmaceutical Sciences and Research"},{"key":"e_1_2_23_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7046"},{"key":"e_1_2_23_16_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.46.9.1481"},{"key":"e_1_2_23_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2007.04.002"},{"key":"e_1_2_23_18_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-825760"},{"key":"e_1_2_23_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.1998.tb02281.x"},{"key":"e_1_2_23_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0001-6349.2004.00314.x"},{"key":"e_1_2_23_21_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-0600"},{"issue":"2","key":"e_1_2_23_22_1","first-page":"47","article-title":"Alpha lipoic acid prevents pancreatic islet cells damage and dyslipidemia in streptozotocin\u2010induced diabetic rats","volume":"14","author":"Budin S. 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