{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T17:18:02Z","timestamp":1794071882257,"version":"4.8.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,2,17]],"date-time":"2022-02-17T00:00:00Z","timestamp":1645056000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Rheumatoid arthritis (RA) is a chronic inflammatory disease that leads to cartilage damage with mostly accompanied by metabolic disorders. This study aimed to investigate the effects of curcumin supplementation on metabolic parameters (lipid profile and glycemic indices), inflammatory factors, visfatin levels, and obesity values in women with RA. This randomized, double\u2010blind, placebo\u2010controlled clinical trial was conducted on 48 women with RA. The patients were treated with curcumin (500\u2009mg once a day) or placebo for 8\u2009weeks. Fasting blood samples, anthropometric measurements, dietary intakes, and physical activity levels of subjects were collected at baseline and the end of the study. Curcumin supplementation significantly decreased homeostatic model assessment for insulin resistance (HOMA\u2010IR), erythrocyte sedimentation rate, serum levels of high\u2010sensitivity C\u2010reactive protein and triglycerides, weight, body mass index, and waist circumference of patients compared with the placebo at the end of the study (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05 for all). HOMA\u2010IR and triglyceride levels significantly increased within the placebo group. Changes in fasting blood sugar, insulin, other lipids profile, and visfatin levels were not significant in any of the groups (<jats:italic>p<\/jats:italic>\u2009&gt;\u2009.05). These results support the consumption of curcumin, as a part of an integrated approach to modulate metabolic factors, inflammation, and adiposity in women with RA.<\/jats:p>","DOI":"10.1002\/ptr.7422","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T06:12:40Z","timestamp":1645164760000},"page":"1797-1806","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Effects of curcumin supplementation on metabolic parameters, inflammatory factors and obesity values in women with rheumatoid arthritis: A randomized, double\u2010blind, placebo\u2010controlled clinical trial"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7285-8338","authenticated-orcid":false,"given":"Fatemeh","family":"Pourhabibi\u2010Zarandi","sequence":"first","affiliation":[{"name":"Student Research Committee, Faculty of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Nutrition Research Center, Faculty of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2593-1253","authenticated-orcid":false,"given":"Maryam","family":"Rafraf","sequence":"additional","affiliation":[{"name":"Nutrition Research Center, Faculty of Nutrition and Food Science Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Habib","family":"Zayeni","sequence":"additional","affiliation":[{"name":"Guilan Rheumatology Research Center, Department of Rheumatology, Razi Hospital, School of Medicine Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Asghari\u2010Jafarabadi","sequence":"additional","affiliation":[{"name":"Department of Statistics and Epidemiology, Faculty of Health Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Road Traffic Injury Research Center Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali\u2010Asghar","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Connective Tissue Diseases Research Center Tabriz University of Medical Sciences  Tabriz Iran"},{"name":"Internal Medicine Department, Faculty of Medicine Tabriz University of Medical Sciences  Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,17]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/343746"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6328"},{"issue":"3","key":"e_1_2_10_4_1","first-page":"1","article-title":"Quality of life and related factors in rheumatoid arthritis patients","volume":"2","author":"Akhlaghi M.","year":"2016","journal-title":"Journal of Health Research in Community"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctim.2019.02.014"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.10416"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2013.09.013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00394-019-01916-7"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1249\/01.MSS.0000078924.61453.FB"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22053"},{"issue":"21","key":"e_1_2_10_11_1","first-page":"4195","article-title":"Potential role of bioavailable curcumin in weight loss and omental adipose tissue decrease: Preliminary data of a randomized, controlled trial in overweight people with metabolic syndrome. 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