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In their medical textbooks and pharmacopeias, Persian great scientists such as Rhazes (854\u2013925\u2009AD), Avicenna (980\u20131037\u2009AD), and Jorjani (1042\u20131136\u2009AD), have discussed pharmacological and nutritional strategies for the prevention, slowing progression, and treatment of PD. In the present study, we surveyed plant\u2010 and animal\u2010based foods recommended by PM for the prevention and treatment of CNS\u2010related tremors. In vivo and in\u2010vitro pharmacological evidence supporting the beneficial effects of PM\u2010recommended foods in prevention and alleviating PD, major active phytochemicals along with the relevant mechanisms of action were studied. Several PM plants possess potent antioxidant, antiinflammatory, and PD preventing properties. Garlic and allicin, cabbage and isothiocyanates, chickpea seed and its O\u2010methylated isoflavones biochanin A and formononetin, cinnamon, and cinnamaldehyde, saffron and its crocin, crocetin, and safranal, black cumin and its thymoquinone, black pepper and piperine, pistachio and genistein and daidzein, and resveratrol are among the most effective dietary itemsagainst PD. They act through attenuating neurotoxin\u2010induced memory loss and behavioral impairment, oxidative stress, and dopaminergic cell death. PM\u2010recommended foods can help alleviate PD progression and also discovering and developing new neuroprotective anti\u2010PD pharmaceuticals.<\/jats:p>","DOI":"10.1002\/ptr.7425","type":"journal-article","created":{"date-parts":[[2022,3,4]],"date-time":"2022-03-04T12:14:29Z","timestamp":1646396069000},"page":"1952-1989","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms"],"prefix":"10.1002","volume":"36","author":[{"given":"Milad","family":"Iranshahy","sequence":"first","affiliation":[{"name":"Department of Pharmacognosy School of Pharmacy, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behjat","family":"Javadi","sequence":"additional","affiliation":[{"name":"Department of Traditional Pharmacy School of Pharmacy, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8656-1444","authenticated-orcid":false,"given":"Amirhossein","family":"Sahebkar","sequence":"additional","affiliation":[{"name":"Applied Biomedical Research Center, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences  Mashhad Iran"},{"name":"School of Medicine, The University of Western Australia  Perth Australia"},{"name":"Department of Biotechnology School of Pharmacy, Mashhad University of Medical Sciences  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,4]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17081293"},{"issue":"3","key":"e_1_2_9_3_1","first-page":"35","article-title":"Neuroprotective role of chrysin in attenuating loss of dopaminergic neurons and improving motor, learning and memory functions in rats","volume":"12","author":"Ahmed M. 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