{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T06:42:50Z","timestamp":1764225770774,"version":"3.40.5"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,13]],"date-time":"2022-03-13T00:00:00Z","timestamp":1647129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100007847","name":"Natural Science Foundation of Jilin Province","doi-asserted-by":"publisher","award":["JLSCZD2019\u2010019"],"award-info":[{"award-number":["JLSCZD2019\u2010019"]}],"id":[{"id":"10.13039\/100007847","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Oxidative stress and inflammation play important roles in pleurisy. Leonurine (Leo) has been confirmed to exert antioxidative and antiinflammatory effects in many preclinical experiments, but these effects have not been studied in pleurisy. The aim of this study was to explore the therapeutic effect and mechanism of Leo in a carrageenan (CAR)\u2010induced pleurisy model. In this study, we found that the increase of reactive oxygen species (ROS), myeloperoxidase (MPO), and malondialdehyde (MDA) and decrease of glutathione (GSH) induced by CAR could be reversed by the treatment of Leo. Leo effectively reduced the levels of proinflammatory cytokines interleukin\u20101\u03b2 (IL\u20101\u03b2), tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), and the percentages of mature macrophages and increased the levels of antiinflammatory cytokines (IL\u201010). Furthermore, Western blotting revealed that Leo significantly activated the Nrf2 pathway to restrain the thioredoxin\u2010interacting protein\/NOD\u2010like receptor protein 3 (TXNIP\/NLRP3) and nuclear factor kappa\u2010B (NF\u2010\u03baB) pathways. However, the protective effect of Leo was significantly weakened in Nrf2\u2010deficient mice. These results indicate that Leo confers potent protection against CAR\u2010induced pleurisy by inhibiting the TXNIP\/NLRP3 and NF\u2010\u03baB pathways dependent on Nrf2, which may serve as a promising agent for attenuating pleurisy.<\/jats:p>","DOI":"10.1002\/ptr.7437","type":"journal-article","created":{"date-parts":[[2022,3,14]],"date-time":"2022-03-14T01:35:22Z","timestamp":1647221722000},"page":"2161-2172","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Leonurine inhibits the TXNIP\/NLRP3 and NF\u2010\u03baB pathways via Nrf2 activation to alleviate carrageenan\u2010induced pleurisy in mice"],"prefix":"10.1002","volume":"36","author":[{"given":"Kun","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine The First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianqiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine The First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianhua","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2207-6869","authenticated-orcid":false,"given":"Xinxin","family":"Ci","sequence":"additional","affiliation":[{"name":"Institute of Translational Medicine The First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liping","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine The First Hospital of Jilin University  Changchun China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,3,13]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_11_2_1","DOI":"10.3389\/fphar.2019.00775"},{"doi-asserted-by":"publisher","key":"e_1_2_11_3_1","DOI":"10.1111\/jpi.12389"},{"doi-asserted-by":"publisher","key":"e_1_2_11_4_1","DOI":"10.3389\/fimmu.2020.556526"},{"doi-asserted-by":"publisher","key":"e_1_2_11_5_1","DOI":"10.1016\/j.redox.2013.07.005"},{"volume-title":"Pleurisy","year":"2021","author":"Hunter M. 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