{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T03:40:36Z","timestamp":1788234036798,"version":"build-2803163510"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T00:00:00Z","timestamp":1647907200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Experimental and some clinical studies have shown beneficial effects of rosemary leaf on liver function and biochemical parameters. The present study aimed to examine the impact of rosemary leaf powder with a weight loss diet in patients with nonalcoholic fatty liver disease. In a randomized double\u2010blinded clinical trial, 110 patients were randomly assigned to receive either 4\u00a0g rosemary leaf or placebo (starch) powders for 8\u2009weeks. In addition, all participants in the study were given weight loss diet and physical activity recommendations. Compared with baseline, alanine aminotransferase (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001), aspartate aminotransferase (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001), alkaline phosphatase (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001), gamma glutamyltransferase (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001), fasting blood glucose (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001), fasting insulin (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001), insulin resistance (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001), total cholesterol (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.003), triglyceride (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001), low\u2010density lipoprotein cholesterol (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0&lt;\u2009.001), and anthropometric indices (weight, body mass index, and waist circumferences) decreased significantly in the rosemary and placebo group with weight loss. However, after 8\u2009weeks, no significant difference between the rosemary and placebo groups was detected in the variables as mentioned above except homeostasis model assessment of \u03b2\u2010cell dysfunction (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u2009.014). The findings of the current clinical trial study revealed that rosemary group did produce changes, but they were not statistically different from those produced by the diet\/activity intervention alone.\n                  <\/jats:p>","DOI":"10.1002\/ptr.7446","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T20:28:52Z","timestamp":1647980932000},"page":"2186-2196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of rosemary leaf powder with weight loss diet on lipid profile, glycemic status, and liver enzymes in patients with nonalcoholic fatty liver disease: A randomized, double\u2010blind clinical trial"],"prefix":"10.1002","volume":"36","author":[{"given":"Shayan","family":"Akbari","sequence":"first","affiliation":[{"name":"Department of Nutrition School of Public Health, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6723-7112","authenticated-orcid":false,"given":"Mohammad Hassan","family":"Sohouli","sequence":"additional","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeedeh","family":"Ebrahimzadeh","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Public Health, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariborz Mansour","family":"Ghanaei","sequence":"additional","affiliation":[{"name":"Gastrointestinal and Liver Diseases Research Center, Guilan University of Medical Sciences  Rasht Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agha Fatemeh","family":"Hosseini","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Public Health, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naheed","family":"Aryaeian","sequence":"additional","affiliation":[{"name":"Department of Nutrition School of Public Health, Iran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,3,22]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-7075-10-19"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5897\/AJBR2014.0765"},{"issue":"1","key":"e_1_2_9_4_1","first-page":"87","article-title":"Effect of rosemary on fasting blood glucose, hemoglobin A1c and vitamin B12 in healthy person and type 2 diabetic patients taking glucomid or\/and metformin","volume":"8","author":"Al Shawabkeh M. 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