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The antiinflammatory effects of luteolin have been reported. In this study, the effect of luteolin on allergic diseases and the underlying molecular mechanism were investigated. We found that luteolin inhibits Fc epsilon R\u0399 (Fc\u03b5R\u0399)\u2010 and Mas\u2010related G protein\u2010coupled receptor X2 (MRGPRX2)\u2010mediated mast cells (MCs) activation, including degranulation and release of cytokines in vitro. Moreover, luteolin reduces the degree of swelling and Evans blue exudation of mice paw in a dose\u2010dependent manner. The concentrations of histamine, TNF\u2010\u03b1, MCP\u20101, IL\u20108, and IL\u201013 in mice serum are also decreased by luteolin administration. Our study reveals that luteolin can inhibit Fc\u03b5R\u0399\u2010 and MRGPRX2\u2010mediated allergic responses in vivo and in vitro, and our results discover luteolin inhibited mast cells mediated anaphylactic reaction by inhibiting the phosphorylation level of PLC\u03b3.<\/jats:p>","DOI":"10.1002\/ptr.7447","type":"journal-article","created":{"date-parts":[[2022,3,22]],"date-time":"2022-03-22T04:25:46Z","timestamp":1647923146000},"page":"2197-2206","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Luteolin inhibits <scp>Fc\u03b5R\u0399<\/scp>\u2010 and <scp>MRGPRX2<\/scp>\u2010mediated mast cell activation by regulating calcium signaling pathways"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8617-0243","authenticated-orcid":false,"given":"Yong","family":"Hao","sequence":"first","affiliation":[{"name":"Department of Dermatology, Northwest Hospital The Second Affiliated 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