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Therefore, there is a still vivid interest in finding alternate re\u2010purposed drugs and nutrition supplements, which can halt or slow the disease severity. We review here the multiple preclinical studies, partially supported by clinical evidence showing the quercetin's possible therapeutic\/prophylaxis efficacy against severe acute respiratory syndrome coronavirus (SARS\u2010CoV) as well as comorbidities like chronic obstructive pulmonary disease (COPD), diabetes mellitus, obesity, coagulopathy, and hypertension. Currently, 14 interventional clinical trials are underway assessing the efficacy of quercetin along with other antiviral drugs\/nutritional supplements as prophylaxis\/treatment option against COVID\u201019. The present review is tempting to suggest that, based on circumstantial scientific evidence and preliminary clinical data, the flavonoid quercetin can ameliorate COVID\u201019 infection and symptoms acting in concert on two parallel and independent paths: inhibiting key factors responsible for SARS\u2010CoV\u20102 infections and mitigating the clinical manifestations of the disease in patients with comorbid conditions. Despite the broad therapeutic properties of quercetin, further high power randomized clinical trials are needed to firmly establish its clinical efficacy against COVID\u201019.<\/jats:p>","DOI":"10.1002\/ptr.7461","type":"journal-article","created":{"date-parts":[[2022,4,8]],"date-time":"2022-04-08T04:58:37Z","timestamp":1649393917000},"page":"2394-2415","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["A critical evaluation of risk to reward ratio of quercetin supplementation for\n                    <scp>COVID<\/scp>\n                    \u201019 and associated comorbid conditions"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9545-3325","authenticated-orcid":false,"given":"Anil","family":"Pawar","sequence":"first","affiliation":[{"name":"Department of Zoology DAV University  Jalandhar 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