{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:46:49Z","timestamp":1784774809577,"version":"3.55.0"},"reference-count":39,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T00:00:00Z","timestamp":1650412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771947"],"award-info":[{"award-number":["81771947"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Hepatocellular carcinoma (HCC) is one of the most common malignant tumors worldwide. Herbal medicines have become an important treasure reservoir for anti\u2010HCC drugs because of their high efficiency and low toxicity. Herein, we investigated whether a 75% ethanol extract from Resina Draconis (ERD) exhibited comprehensive anti\u2010HCC effects both in vivo and in vitro. We revealed that ERD effectively inhibited proliferation and triggered apoptosis of HCC cells in a dose\u2010 and time\u2010dependent maner, posing no apparent apoptotic toxicity to normal liver cells. Moreover, ERD significantly inhibited the migration, invasion and metastasis of HCC cells. Importantly, ERD treatment effectively inhibited the growth of xenograft HCC in nude mice with low toxicity and low side effects. Molecular mechanism analysis showed that ERD strongly reduced the expression of anti\u2010apoptotic protein Survivin, ultimately leading to the cleavage activation of apoptosis executive proteins such as Caspase 3 and Poly (ADP\u2010ribose) polymerase (PARP). Survivin gene silencing apparently sensitized the apoptotic effect induced by ERD. Further experiments revealed that ERD inhibited N6\u2010methyladenosine (m\n                    <jats:sup>6<\/jats:sup>\n                    A) modification in Survivin mRNA by downregulating Methyltransferase\u2010like 3 (METTL3) expression and reducing the binding rate of METTL3 and Survivin mRNA. Together, our findings suggest that ERD can be severed as a novel anti\u2010HCC natural product by targeting METTL3\u2010m\n                    <jats:sup>6<\/jats:sup>\n                    A\u2010Survivin axis.\n                  <\/jats:p>","DOI":"10.1002\/ptr.7467","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T13:15:35Z","timestamp":1650460535000},"page":"2542-2557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Resina Draconis extract exerts\n                    <scp>anti\u2010HCC<\/scp>\n                    effects through\n                    <scp>METTL3\u2010m6A\u2010Survivin<\/scp>\n                    axis"],"prefix":"10.1002","volume":"36","author":[{"given":"Linlin","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Radiology Shengjing Hospital of China Medical University  Shenyang Liaoning 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