{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T02:05:05Z","timestamp":1793844305605,"version":"4.6.1"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81874404; TCM Research Project of Guangdong Provincial Bureau of TCM, Grant\/Award Number: 20222171; Guangzhou TCM and Integrated Traditional Chinese and Western Medicine Science and Technology Project, Grant\/Award Number: 202185151002"],"award-info":[{"award-number":["81874404; TCM Research Project of Guangdong Provincial Bureau of TCM, Grant\/Award Number: 20222171; Guangzhou TCM and Integrated Traditional Chinese and Western Medicine Science and Technology Project, Grant\/Award Number: 202185151002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Therapeutic drugs of chronic neuralgia have a high risk of addiction, making it crucial to identify novel drugs for chronic neuralgia. This study aimed to explore the therapeutic effect of paeoniflorin on chronic sciatica via inhibiting Schwann cell apoptosis. 28 SD rats were randomly divided into four groups, including the sham operation group, chronic constriction injury (CCI) group, mecobalamin group, and paeoniflorin group. The therapeutic effect and mechanism of paeoniflorin were evaluated via rat and cell experiments. Mechanical, hot, or cold hyperalgesia was induced in the rats after CCI operation, while paeoniflorin relieved chronic neuralgia. Besides, paeoniflorin decreased the levels of IL1, IL6, TNF\u2010\u03b1, CRP, and LPS and increased the level of IL10 in serum. As for the sciatic nerve, the number of inflammatory cells was decreased, and Schwann cells were present after paeoniflorin treatment, and paeoniflorin promoted the recovery of nerve structure. In cell experiments, LPS induced Schwann cell apoptosis via the TLR4\/NF\u2010kB pathway. And paeoniflorin attenuated LPS\u2010induced Schwann cell apoptosis by decreasing the levels of TLR4, p\u2010NF\u2010kB, caspase3, cleaved\u2010caspase3, and cleaved\u2010caspase7. Overall, these results suggest that paeoniflorin alleviates chronic sciatica by decreasing inflammatory factor levels and promotes the repair of damaged nerves by reducing Schwann cell apoptosis.<\/jats:p>","DOI":"10.1002\/ptr.7472","type":"journal-article","created":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T08:30:00Z","timestamp":1651480200000},"page":"2572-2582","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Therapeutic effect of paeoniflorin on chronic constriction injury of the sciatic nerve via the inhibition of Schwann cell apoptosis"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9134-6573","authenticated-orcid":false,"given":"Di","family":"Zhang","sequence":"first","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3888-9282","authenticated-orcid":false,"given":"Shiquan","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1594-2378","authenticated-orcid":false,"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9026-5149","authenticated-orcid":false,"given":"Huimei","family":"Shi","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8208-2323","authenticated-orcid":false,"given":"Bei","family":"Jing","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8040-8927","authenticated-orcid":false,"given":"Zhenni","family":"Chen","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Lin","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0885-8258","authenticated-orcid":false,"given":"Yachun","family":"Zheng","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3036-1512","authenticated-orcid":false,"given":"Guoqiang","family":"Qian","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine, Guangdong Pharmaceutical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3670-9877","authenticated-orcid":false,"given":"Yuwei","family":"Pan","sequence":"additional","affiliation":[{"name":"Preventive Treatment of Disease,Tianhe Hospital of Traditional Chinese Medicine  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5577-2329","authenticated-orcid":false,"given":"Guoping","family":"Zhao","sequence":"additional","affiliation":[{"name":"College of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22083948"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.56935"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03706-8"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10092500"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13770-020-00329-6"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3171\/2017.5.Spine161100"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.109812"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2011.00010"},{"key":"e_1_2_11_10_1","unstructured":"Institute of Laboratory Animal Resources (U.S.).Committee on Care and Use of Laboratory Animals. 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