{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T18:34:01Z","timestamp":1772649241595,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2001,8,17]],"date-time":"2001-08-17T00:00:00Z","timestamp":998006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2001,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Elevated levels of immunoglobulin (Ig)E are associated with immediate\u2010type allergic reactions. The effect of an aqueous extract of <jats:italic>Siegesbeckia glabrescens<\/jats:italic> (Compositae) whole plants (SGWP) on <jats:italic>in vivo<\/jats:italic> and <jats:italic>in vitro<\/jats:italic> IgE production was studied in mice. SGWP dose\u2010dependently inhibited the active systemic anaphylaxis and serum IgE production induced by immunization with ovalbumin and <jats:italic>Bordetella pertussis<\/jats:italic> toxin absorbed to aluminium hydroxide gel. SGWP dose\u2010dependently inhibited IL\u20104\u2010dependent IgE production by lipopolysaccharide\u2010stimulated murine whole spleen cells. In the case of U266 human IgE\u2010bearing B cells, SGWP also showed an inhibitory effect on IgE production. These results suggest that SGWP has an anti\u2010allergic activity by inhibiting IgE production from B cells. 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