{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:12Z","timestamp":1786978392584,"version":"build-2736575974"},"reference-count":55,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T00:00:00Z","timestamp":1656720000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Psoriasis (PSO), an immune\u2010mediated chronic inflammatory skin disease, has seriously affected the quality of patients' life. It is urgent to find effective medicines with lower costs and less side effects. Baicalin (HQG) is the main bioactive substance from\n                    <jats:italic>Scutellaria baicalensis<\/jats:italic>\n                    with effects of anti\u2010inflammation and immunoregulation. Herein, we explored the effect of oral HQG treating PSO and its potential mechanism. Firstly, network pharmacology was used to predict that HQG may act on Estrogen, TNF\u2010alpha (tumor necrosis factor, TNF), interleukin\u201017 (IL\u201017) signaling pathways and Th17 cell differentiation, especially the key targets including TNF, Proto\u2010oncogene tyrosine\u2010protein kinase Src, Peroxisome proliferator\u2010activated receptor gamma and Matrix metalloproteinase\u20109. Imiquimod (IMQ)\u2010induced mice were then used to study the effects of HQG treating PSO. HQG could significantly ameliorate the skin lesions, decrease the level of inflammatory factors and inhibit Th1\/Th17 cell differentiation in IMQ\u2010induced mice. Finally, transcriptome analysis of skin lesions integrated with the prediction of network pharmacology further demonstrated that the potential mechanism may be associated with suppressing Wnt signaling pathway and inhibiting Th17\/IL\u201017 axis by activating PPAR\u03b3. In conclusion, this study suggested that HQG may be a promising agent for further studies in the search for therapeutic strategies to treat PSO in the future.\n                  <\/jats:p>","DOI":"10.1002\/ptr.7546","type":"journal-article","created":{"date-parts":[[2022,7,2]],"date-time":"2022-07-02T04:54:30Z","timestamp":1656737670000},"page":"3969-3987","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Potential mechanism of oral baicalin treating psoriasis via suppressing Wnt signaling pathway and inhibiting Th17\/\n                    <scp>IL<\/scp>\n                    \u201017 axis by activating\n                    <scp>PPAR\u03b3<\/scp>"],"prefix":"10.1002","volume":"36","author":[{"given":"Yi","family":"Chen","sequence":"first","affiliation":[{"name":"Hospital of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College  Nanjing 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