{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:53:44Z","timestamp":1786978424176,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T00:00:00Z","timestamp":1658016000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Phytotherapy Research"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Globally, Non\u2010alcoholic fatty liver disease (NAFLD) has a rising prevalence with no definitive pharmacological treatments. The aim of this study was to assess the clinical effects of wheat germ in patients with NAFLD. Fifty participants with NAFLD were randomly allocated to take 40\u2009g wheat germ (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200925) or placebo (\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u200925) in a randomized double\u2010blind clinical trial over 12\u2009weeks. Transient elastography (FibroScan) determined a diagnosis of NAFLD. After 12\u2009weeks of intervention, reduction in serum alanine aminotransferase (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.006) and \u03b3\u2010glutamyltransferase (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.004), total cholesterol (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.018), triglyceride (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.046), and hepatic steatosis (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.043) levels in the wheat germ group was significantly higher compared to the placebo group. Serum TAC levels in wheat germ group patients increased significantly higher than placebo group (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.001). Reduction in serum hs\u2010CRP level in the wheat germ group was significantly higher than in the placebo group (\n                    <jats:italic>p<\/jats:italic>\n                    \u00a0=\u20090.031). In conclusion, our study shows that wheat germ consumption may improve total antioxidant capacity, hepatic steatosis, serum total cholesterol and triglyceride levels, alanine aminotransferase (ALT), and Gamma\u2010glutamyl Transferase (GGT) in NAFLD patients. Longitudinal studies with larger sample sizes are needed to confirm biological effects of wheat germ on NAFLD patients.\n                  <\/jats:p>","DOI":"10.1002\/ptr.7553","type":"journal-article","created":{"date-parts":[[2022,7,17]],"date-time":"2022-07-17T19:14:10Z","timestamp":1658085250000},"page":"4201-4209","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Wheat germ improves hepatic steatosis, hepatic enzymes, and metabolic and inflammatory parameters in patients with nonalcoholic fatty liver disease: A randomized, placebo\u2010controlled, double\u2010blind clinical trial"],"prefix":"10.1002","volume":"36","author":[{"given":"Ammar","family":"Salehi\u2010Sahlabadi","sequence":"first","affiliation":[{"name":"Department of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Research Institute Shahid Beheshti University of Medical Sciences  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