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Chemotherapy is toxic for both normal and cancer cells and can induce unfavorable conditions, such as chemotherapy\u2010induced nausea and vomiting (CINV), that reduce patients' quality of life. Emesis after chemotherapy is categorized into two classes acute and delayed. Since ancient times, herbal medicines have been used in various cultures to manage stomachache, vomiting, and nausea. In this manuscript, the antiemetic mechanisms of several herbal medicines and their preparations such as <jats:italic>Zingiber officinale<\/jats:italic> (5\u2010HT, NK\u20101 receptor and muscarinic antagonist activity), <jats:italic>Mentha spicata<\/jats:italic> (5\u2010HT antagonist activity), <jats:italic>Scutellaria baicalensis<\/jats:italic> (antioxidant activity<jats:bold>)<\/jats:bold>, Persumac (useful in delayed phase through antioxidant, anti\u2010inflammatory, and anti\u2010contractile properties) and Rikkunshito (supportive in acute and delayed phase through 5\u2010HT receptor antagonist activity) have been reviewed to show their potential effects on decreasing CINV and attract scientists attention to formulate more herbal medicine to alleviate CINV in cancer patients. However, it is crucial to say that additional high\u2010quality investigations are required to firmly verify the clinical effectiveness and safety of each plant\/compound.<\/jats:p>","DOI":"10.1002\/ptr.7563","type":"journal-article","created":{"date-parts":[[2022,7,16]],"date-time":"2022-07-16T06:59:29Z","timestamp":1657954769000},"page":"3691-3708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Medicinal herbs in treating chemotherapy\u2010induced nausea and vomiting: A review"],"prefix":"10.1002","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6115-7800","authenticated-orcid":false,"given":"Reza","family":"Rajabalizadeh","sequence":"first","affiliation":[{"name":"Department of Pharmacodynamics and Toxicology School of Pharmacy, Mashhad University of Medical Sciences  Mashhad 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